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他汀类药物不良反应分析
引用本文:温晓娜. 他汀类药物不良反应分析[J]. 中国医药导刊, 2011, 13(1): 128-129
作者姓名:温晓娜
作者单位:天津市第三中心医院药剂科,天津,300170
摘    要:
目的:探讨他汀类药物所致不良反应的特点及相关因素,为临床合理用药提供参考。方法:查阅《中国医院知识仓库(CHKD)全文期刊库》(1998~2008)年他汀类药物致不良反应的有关文献60篇(共66例)进行统计分析。结果:他汀类所致不良反应多发生在(51~80)岁年龄段,集中发生在给药后30天内,主要表现为肌肉毒性、肝脏毒性、过敏反应等方面。结论:临床医师和药师应重视他汀类药物的不良反应,促进其合理应用。

关 键 词:他汀类药物  不良反应  文献分析

Analysis of Adverse Drug Reactions Induced by Statins
Wen Xiao-na. Analysis of Adverse Drug Reactions Induced by Statins[J]. Chinese Journal of Medicinal Guide, 2011, 13(1): 128-129
Authors:Wen Xiao-na
Affiliation:Wen Xiao-na (Department of Pharmacy,The Third Central Hospital of Tianjin,Tianjin 300170,China)
Abstract:
Objective:To provide a rational of clinical drug safety by analyzing the adverse drug reactions(ADR)caused by Statins. Methods:60 Statins-reduced ADR reports(66 cases) published in China Hospital Knowledge Database from 1998 to 2008 was analyzed statistically.Results:The ADR induced by Statins were more often occurred in patients aged from 51 to 80,usually appeared within 30 day after drug use.The clinical presentation were seen in the toxic reactions of muscle,the toxic reactions of liver,allergic,ect.Conclusion: Clinician and pharmacists should attach great importance to statin-induced ADR in clinical practice and promote its rational use.
Keywords:Statins  Adverse drug reactions  Literature analysis
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