| 川陈皮素温敏型鼻用原位凝胶体外释药行为研究 |
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| 引用本文： | 谢悦良,范景辉,丁劲松,裴齐,张毕奎. 川陈皮素温敏型鼻用原位凝胶体外释药行为研究[J]. 中国医药工业杂志, 2011, 42(3) |
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| 作者姓名： | 谢悦良 范景辉 丁劲松 裴齐 张毕奎 |
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| 作者单位： | 1. 中南大学湘雅三医院药剂科;中南大学药学院,湖南长沙,410013
2. 中南大学药学院,湖南长沙,410013 |
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| 基金项目： | 湖南省卫生厅科研基金课题 |
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| 摘 要： | 分别采用扩散池法、无膜溶出法以及渗析池法考察川陈皮素温敏型鼻用原位凝胶的体外释药特性与机制.结果表明,川陈皮素原位凝胶通过扩散释放的药物量较少,150 min仅为1.4%;通过无膜溶出法药物释放完全,120 min时药物基本释放完全,且药物的释放量与溶蚀量具有良好的相关性.渗析池法药物的释放量较扩散池法多,120min可释放8%的药物.因此,本实验室研制的川陈皮素温敏型鼻用原位凝胶可能主要通过溶蚀方式释药.
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| 关 键 词： | 川陈皮素 温敏型鼻用原位凝胶 泊洛沙姆 体外释放 |
In vitro Release of Nobiletin Thermosensitive Nasal in situ Gel |
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| ME Yueliang,FAN Jinghui,DING Jinsong,PEI Qi,ZHANG Bikui. In vitro Release of Nobiletin Thermosensitive Nasal in situ Gel[J]. , 2011, 42(3) |
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| Authors: | ME Yueliang FAN Jinghui DING Jinsong PEI Qi ZHANG Bikui |
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| Affiliation: | XIE Yueliang1,2,FAN Jinghui1,DING Jinsong2,PEI Qi1,ZHANG Bikui1,2(1.Dept.of Pharmacy,Third Xiangya Hospital of Central South University,2.School of Pharmaceutical Sciences,Central South University,Changsha 410013) |
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| Abstract: | Three methods including Franz diffusion cell,membrane-free and dialysis cell were used separately to study the in vitro drug release characteristics and mechanism of nobiletin thermosensitive nasal in situ gel.The results showed that only 1.4% nobiletin was released in 150 min by diffusion from thermosensitive nasal in situ gel using Franz diffusion cell.The drug was mostly released in 120 min by erosion.And erosion rate of the gel was linearly correlated with the drug release rate.Only 8% nobiletin was rel... |
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| Keywords: | nobiletin thermosensitive nasal in situ gel poloxamer in vitro release |
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