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| 3-羟基-2-萘醛缩氨基硫脲稀土配合物的合成及其与DNA的相互作用 | |
| 引用本文： | 杨欢春,杨天林,王丽娟. 3-羟基-2-萘醛缩氨基硫脲稀土配合物的合成及其与DNA的相互作用[J]. 中国医药工业杂志, 2011, 42(3) |
| 作者姓名： | 杨欢春 杨天林 王丽娟 |
| 作者单位： | 1. 宁夏大学能源化工重点实验室,宁夏银川,750021;宁夏疾病预防控制中心,宁夏银川,750001 2. 宁夏大学能源化工重点实验室,宁夏银川,750021 |
| 基金项目： | 教育部科学基金重点项目，宁夏高校科学研究基金 |
| 摘 要： | 合成了3-羟基-2-萘醛缩氨基硫脲及其稀土配合物,通过IR、UV、元素分析、摩尔电导及热分析等进行了结构表征.在pH 7.22的Tris-HC1缓冲液中,采用紫外光谱、荧光光谱和黏度法研究了目标化合物与ct-DNA的相互作用.结果表明该化合物以插入式与ct-DNA键合. |
| 关 键 词： | 3-羟基-2-萘醛 氨基硫脲 希夫碱 稀土配合物 合成 |
Synthesis and Interaction with ct-DNA of 3-Hydroxy-2-naphthaldehyde Thiosemicarbazide and Its Rare Earth Complexes |
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| YANG Huanchun,YANG Tianlin,WANG Lijuan. Synthesis and Interaction with ct-DNA of 3-Hydroxy-2-naphthaldehyde Thiosemicarbazide and Its Rare Earth Complexes[J]. , 2011, 42(3) | |
| Authors: | YANG Huanchun YANG Tianlin WANG Lijuan |
| Affiliation: | YANG Huanchun1,2,YANG Tianlin1,WANG Lijuan1(1.Key Lab.of Energy Resources and Chemical Engineering,Ningxia University,Yinchuan 750021,2.Ningxia Centers for Diseases Prevention and Control,Yinchuan 750001) |
| Abstract: | The Schiff base of 3-hydroxy-2-naphthaldehyde with thiosemicarbazide and its rare earth complexes were synthesized.The structure has been characterized by IR,UV,TG-DTA,elements analysis and molar conductance analysis.The interaction between its complexes and ct-DNA has been studied by electronic absorption spectroscopy,fluorescence spectroscopy,viscosity measurement in buffer solution of Tris-HCl(pH 7.22).All of the results indicated that the interaction of the complexes with ct-DNA is intercalation. |
| Keywords: | 3-hydroxy-2-naphthaldehyde thiosemicarbazide Schiff base rare earth complex ct-DNA |
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