| 高效液相色谱法测定丁桂儿脐贴中丁香酚和桂皮醛含量 |
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| 引用本文： | 王也,裘国丽,黄华.高效液相色谱法测定丁桂儿脐贴中丁香酚和桂皮醛含量[J].中国药业,2011,20(10):43-44. |
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| 作者姓名： | 王也 裘国丽 黄华 |
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| 作者单位： | 1. 浙江省衢州市食品药品检验所,浙江,衢州,324002
2. 杭州民生药业集团公司,浙江,杭州,310011 |
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| 摘 要： | 目的 建立测定丁桂儿脐贴的丁香酚和桂皮醛含量的高效液相色谱法.方法 采用Eclipse XDB-C18色谱柱(150mm×4.6mm,5μm),以甲醇-水(65∶35)为流动相,检测波长280 nm,流速1.0 mL/min.结果 丁香酚进样量在0.172 9～2.074 2 μg范围内与峰面积线性关系良好(r=0.999 9),平均回收率为96.98%,RSD为1.85%(n=6);桂皮醛进样量在0.003 4～0.273 2μg范围内与峰面积线性关系良好(r=0.9999),平均回收率为97.90%,RSD为1.55%(n=6).结论 该方法简便、准确、可靠、精密度高,可用于丁桂儿脐贴的质量控制.
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| 关 键 词： | 丁桂儿脐贴 高效液相色谱法 丁香酚 桂皮醛 含量测定 |
Determination of Eugenol and Cinnamaldehyde in Dingguier Umbilical Paste by HPLC |
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| Wang Ye,Qiu Guoli,Huang Hua.Determination of Eugenol and Cinnamaldehyde in Dingguier Umbilical Paste by HPLC[J].China Pharmaceuticals,2011,20(10):43-44. |
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| Authors: | Wang Ye Qiu Guoli Huang Hua |
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| Institution: | Wang Ye1,Qiu Guoli2,Huang Hua1(1.Quzhou Institute for Drug Control,Quzhou,Zhejiang,China 324002,2.Hangzhou Minsheng Pharmaceutical Group Co.,Ltd.,Hangzhou,China 310011) |
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| Abstract: | Objective To establish a method for the determination of eugenol and cinnamaldehyde in Dingguier Umbilical Paste.Methods The Eclipse XDB-C18 column（150 mm×4.6 mm,5 μm） was used with the mobile phase of methanol-water（65 ∶35）.The detection wavelength was 280 nm and the flow rate was 1.0 mL/min.Results Eugenol had the good linearity in the range of 0.172 9-2.074 2 μg（r=0.999 9）.The average recovery rate was 96.98%,RSD 1.85%（n=6）.Cinnamaldehyde had the good linearity（r= 0.999 9） in the range of 0.003 4-0.273 2 μg.The average recovery rate was 97.90%,RSD 1.55%（n=6）.Conclusion The method is proved to be simple,accurate and reliable,which can be used to control the quality of Dingguier Umbilical Paste. |
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| Keywords: | Dingguier Umbilical Paste HPLC eugenol cinnamaldehyde content determination |
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