| 4-氯苯乙醇的合成 |
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| 引用本文： | 张立光,於学良,叶蓓.4-氯苯乙醇的合成[J].中国医药工业杂志,2011,42(3). |
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| 作者姓名： | 张立光 於学良 叶蓓 |
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| 作者单位： | 苏州卫生职业技术学院,江苏苏州,215009 |
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| 摘 要： | 以4-氯苯乙酮为原料,经Willgerodt-Kindler法制得4-氯苯乙酸,再在碘存在下经硼氢化钠还原制得杀菌剂腈苯唑的中间体4-氯苯乙醇,总收率约66%.
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| 关 键 词： | 4-氯苯乙醇 腈苯唑 中间体 合成 |
Synthesis of 4-Chlorophenethylalcohol |
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| Authors: | ZHANG Liguang YU Xueliang YE Bei |
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| Institution: | ZHANG Liguang,YU Xueliang,YE Bei(Suzhou Health College of Technology,Suzhou 215009) |
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| Abstract: | 4-Chlorophenethylalcohol,the intermediate of fenbuconazole,was synthesized from 4-chloroacetophenone through Willgerodt-Kindler reaction to give 4-chlorobenzeneacetic acid,followed by reduction with sodium borohydride in the presence of iodine with an overall yield of about 66%. |
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| Keywords: | 4-chlorophenethylalcohol fenbuconazole intermediate synthesis |
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