| 阿仑膦酸钠对假体周围骨溶解中OPG及RANKL的影响 |
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| 引用本文： | 孟海,马立峰,白晓冬,苏楠,郭艾. 阿仑膦酸钠对假体周围骨溶解中OPG及RANKL的影响[J]. 国际外科学杂志, 2011, 38(10): 681-684. DOI: 10.3760/cma.j.issn.1673-4203.2011.10.012 |
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| 作者姓名： | 孟海 马立峰 白晓冬 苏楠 郭艾 |
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| 作者单位： | 首都医科大学附属北京友谊医院骨科, 北京,100050 |
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| 摘 要： | 目的 探讨阿仑膦酸钠对聚乙烯颗粒诱导假体周围骨溶解中OPG及RANKL影响.方法 将钛金属棒植入新西兰大白兔左侧股骨内,每2周向左膝关节内注射聚乙烯颗粒,使用随机数字表随机分成实验组和对照组,各6只.实验组给予阿仑膦酸钠灌胃,而对照组给予等量的0.9％的氯化钠溶液灌胃.12周后处死动物,取出假体周围界膜组织,用ELIS...
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| 关 键 词： | 阿仑膦酸钠 聚乙烯颗粒 OPG RANKL |
Effect of alendronate on OPG and RANKL in periprosthetic osdeolysis induced by polyethylene particles: an experimental study |
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| MENG Hai,MA Li-feng,BAI Xiao-dong,SU Nan,GUO Ai. Effect of alendronate on OPG and RANKL in periprosthetic osdeolysis induced by polyethylene particles: an experimental study[J]. International Journal of Surgery, 2011, 38(10): 681-684. DOI: 10.3760/cma.j.issn.1673-4203.2011.10.012 |
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| Authors: | MENG Hai MA Li-feng BAI Xiao-dong SU Nan GUO Ai |
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| Abstract: | Objective To investigate effect of alendronate on OPG and RANKL in periprosthetic osdeolysis induced by polyethylene particles.Methods Twelve rabbits which had been implanted a titanium plug in femur by intercondylar notch were divided into two groups randomly,polyethylene particles were injected into the left knee joint,one received alendronate,and the other placebo as control.After 12 weeks,all rabbits were sacrificed.Periprosthetic tissues were observed by ELISA.Results The concentration of OPG in the experimental group was not higher than that of the control (P ＞0.05 ).But the concentration of RANKL in the experimental group was lower(P ＜0.01 ).And specific value of OPG/RANKL was higher in the experimental group ( P ＜ 0.05 ).Conclusion The therapy of alendronate can change the concentration of RANKL and specific value of OPG/RANKL in periprosthetic osdeolysis induced by polyethylene particles,inhibit aseptic loosening of prosthesis in rabbits. |
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| Keywords: | Alendronate Polyethylene OPG RANKL |
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