皮肤诺卡菌病诊断与治疗进展

皮肤诺卡菌病是诺卡菌属经皮肤伤口引起的感染,多种诺卡菌均可引起,包括巴西诺卡菌、星形诺卡菌等.皮肤诺卡菌病临床表现无特异性,但以皮下结节伴有瘘管形成最常见.及时、准确的诊断对皮肤诺卡菌病的治疗有重要意义.磺胺类药物仍是治疗皮肤诺卡菌病的一线药物,但耐药株和多重耐药株的发现为临床治疗带来了新的挑战.建立准确的体外药敏谱和选择敏感抗生素对临床用药有指导意义.

Advances in the diagnosis and treatment of cutaneous nocardiosis

Cutaneous nocardiosis is an infection caused by multiple species of Norcardia (including Norcardia brasiliensis,Norcardia asteroides,etc) following skin injury.It has a board spectrum of clinical manifestations with no specificity,and of them,subcutaneous nodules with fistulation are the most common.Accurate and timely diagnosis is crucial to the treatment of primary cutaneous nocardiosis.This article focuses on the advances in molecular diagnosis of cutaneous nocardiosis.Sulfonamides remain the fistline treatment for cutaneous nocardiosis,but the clinical practice is challenged by the emergence of sulfonamide- and multidrug-resistant Nocardia.To develop accurate methods for in vitro drug sensitivity testing and find active antibiotics will provide guidance on clinical medication.