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| 血管旁脂肪组织与糖尿病大血管病变 | |
| 引用本文： | 张福庄,陶红. 血管旁脂肪组织与糖尿病大血管病变[J]. 国际内分泌代谢杂志, 2011, 31(5): 334-336. DOI: 10.3760/cma.j.issn.1673-4157.2011.05.015 |
| 作者姓名： | 张福庄 陶红 |
| 作者单位： | 100029,首都医科大学附属北京安贞医院内分泌科 |
| 基金项目： | 国家自然科学基金，首都医科大学基础-临床科研合作课题 |
| 摘 要： | 糖尿病大血管病变是糖尿病患者致死、致残的首要原因,其主要的病理基础为动脉粥样硬化,但其机制尚未完全阐明.血管旁脂肪组织可分泌众多脂肪细胞因子,研究发现它们不仅参与肥胖、胰岛素抵抗的病理生理过程,还可通过旁分泌和滋养血管分泌“由外至内”作用于血管壁,调节血管张力并参与动脉粥样硬化的发生、发展过程.对血管旁脂肪组织的深入研... |
| 关 键 词： | 糖尿病大血管病变 血管旁脂肪 脂肪细胞因子 肥胖 动脉粥样硬化 |
Perivascular adipose and diabetic macrovascular disease |
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| ZHANG Fu-zhuang,TAO Hong. Perivascular adipose and diabetic macrovascular disease[J]. International JOurnal of Endocrinology and Metabolism, 2011, 31(5): 334-336. DOI: 10.3760/cma.j.issn.1673-4157.2011.05.015 | |
| Authors: | ZHANG Fu-zhuang TAO Hong |
| Abstract: | Diabetic macrovascular disease is the leading cause of death and disability of diabetes,its potential pathological basis is atherosclerosis,but the mechanism is not clear.Perivascular adipose tissue (PVAT) can secret numerous adipokines,they not only participate in pathophysiologic process of obesity and insulin resistance,but also play an important role in regulating arterial tone and development of atherosclerosis through the paracrine and vasocrine way from outside to inside.Therefore,to study PVAT thoroughly will provide a new target for prevention and treatment of diabetic macrovascular disease. |
| Keywords: | Diabetic macrovascular disease Perivascular adipose Adipocytokines Obesity Atherosclerosis |
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