| Fractalkine-CX3CR1与肺疾病 |
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| 引用本文： | 向永红,张云,苏晓丽,胡成平.Fractalkine-CX3CR1与肺疾病[J].国际呼吸杂志,2011,31(22):1755-1760. |
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| 作者姓名： | 向永红 张云 苏晓丽 胡成平 |
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| 作者单位： | 1. 广西壮族自治区民族医院呼吸内科,南宁,530001
2. 410008,长沙中南大学湘雅医院呼吸内科 |
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| 基金项目： | 广西壮族自治区卫生厅项目，湖南省科技厅基金 |
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| 摘 要： | Fractalkine(CX3CL1)是一种独特的趋化因子,是CX3C类惟一的代表,以膜结合型和可溶型两种类型存在,具有黏附和趋化双重作用,CX3CL1与其受体(CX3CR1)结合后可参与细胞的多种生理和病理过程,CX3CL1-CX3CR4表达与感染性肺疾病、肺动脉高压、慢性阻塞性肺疾病、哮喘及肺肿瘤等肺部疾病的发生、...
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| 关 键 词： | 趋化因子 血管重构 肺动脉高压 |
Fractalkine/CX3CR1 and pulmonary diseases |
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| XIANG Yong-hong,ZHANG Yun,SU Xiao-li,HU Cheng-ping.Fractalkine/CX3CR1 and pulmonary diseases[J].International Journal of Respiration,2011,31(22):1755-1760. |
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| Authors: | XIANG Yong-hong ZHANG Yun SU Xiao-li HU Cheng-ping |
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| Abstract: | Fractalkine (CX3CLA) is a unique chemokine.It is the only representa-tive of CX3C group.It exists as a membrane-bound and soluble form.It has dual role of adhesion and chemotactic.CX3CL1 participates in multiple process of physio-logical and pathological after combinning with CX3CR1 in the cells,Expression of CX3CLA-CX3CR1 is closely related to occurrence and development of bronchial and lung diseases,such as Infectious lung disease,pulmonary hypertension,chronic obstructive pulmonary disease,asthma and lung tumor. |
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| Keywords: | Fractalkine Vascular remodeling Pulmonary hypertension |
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