| 血吸虫肝纤维化的病理机制 |
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| 引用本文： | 周寅璞,谢晶,赵雷. 血吸虫肝纤维化的病理机制[J]. 国际流行病学传染病学杂志, 2011, 38(5): 344-348. DOI: 10.3760/cma.j.issn.1673-4149.2011.05.017 |
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| 作者姓名： | 周寅璞 谢晶 赵雷 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院中西医结合科, 武汉,430022 |
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| 摘 要： | 血吸虫肝纤维化主要由宿主对虫卵及其引起的肉芽肿产生免疫应答所致,整个过程主要有中性粒细胞、嗜酸性粒细胞、B细胞、T细胞、肝星形细胞(HSC)等多种细胞参与,并受到TNF-α、IL-1、IL-6、IFN γ等Th1型和IL-4、IL-5、IL-10、IL-13等Th2型细胞因子及一些趋化因子的调控.其反应过程十分复杂,目...
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| 关 键 词： | 血吸虫病 肝纤维化 病理机制 |
Pathogenesis of schistosome egg induced hepatic fibrosis |
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| ZHOU Yin-pu,XIE Jing,ZHAO Lei. Pathogenesis of schistosome egg induced hepatic fibrosis[J]. International Journal of Epidemiology and Infectious Disease, 2011, 38(5): 344-348. DOI: 10.3760/cma.j.issn.1673-4149.2011.05.017 |
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| Authors: | ZHOU Yin-pu XIE Jing ZHAO Lei |
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| Abstract: | Hepatic fibrosis in schistosomiasis is mainly caused by the host immune response to the schistosome eggs and the granuloma induced by eggs.Neutrophils,eosionphils,B cells,T cells,hepatic satellite cells(HSCs),some Th1 cytokines such as TNF-α,IL-1,IL-6,IFN γ,Th2 cytokines such as IL-3,IL-5,IL-10,IL-13 and chemokine are involved in the progress.The whole response is quite complex and the functions of many involved factors are uncertain.In the article,the schistosome granulomas,cell regulation,cytokine and chemokine regulation of hepatic fibrosis are summarized to further clarify the pathogenesis of liver fibrosis in schistosomiasis and new research directions are proposed to provide a reference for future treatment. |
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| Keywords: | Schistosomiasis Hepatic fibrosis Pathogenesis |
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