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毛冬青根的化学成分研究
引用本文:吴婷,张晓琦,王英,叶文才,赵守训. 毛冬青根的化学成分研究[J]. 时珍国医国药, 2009, 20(12)
作者姓名:吴婷  张晓琦  王英  叶文才  赵守训
作者单位:1. 中国药科大学,江苏,南京,210009;暨南大学中药药效物质基础及创新药物研究广东省高校重点实验室,广东,广州,510632
2. 暨南大学中药及天然药物研究所,广东,广州,510632;暨南大学中药药效物质基础及创新药物研究广东省高校重点实验室,广东,广州,510632
3. 中国药科大学,江苏,南京,210009
基金项目:国家自然科学基金,广东省自然科学基金 
摘    要:
目的 研究冬青科植物毛冬青Ilex pubescens Hook. et Arn.根的化学成分.方法 运用多种层析分离方法进行分离纯化,通过理化常数和波谱数据确定化合物的结构.结果 从毛冬青根中分离并鉴定了12个化合物,分别为ilexoside D(1);ilexgenin A(2);spinasterol(3);(+)-fraxiresinol-1-O-β-D-glucoside(4);liriodendrin(5);tortoside A(6);magnolenin C(7);丁香苷(8);sinapic aldehyde 4-O-β-D-glucopyranoside(9);4,5-di-O-caffeoylquinic acid(10);β-谷甾醇(11)和β-胡萝卜苷(12).结论 化合物3,4,10为首次从该属植物中分离得到.

关 键 词:冬青科  毛冬青  化学成分  皂苷

Chemical Constituents from the Roots of Ilex pubescens
WU Ting,ZHANG Xiao-qi,WANG Ying,YE Wen-cai,ZHAO Shou-xun. Chemical Constituents from the Roots of Ilex pubescens[J]. Lishizhen Medicine and Materia Medica Research, 2009, 20(12)
Authors:WU Ting  ZHANG Xiao-qi  WANG Ying  YE Wen-cai  ZHAO Shou-xun
Abstract:
Objective To study the chemical constituents of the roots of Ilex pubescens Hook. et Arn. Methods Chemical constituents were isolated and purified by several column chromatographic methods. The structures were identified by physicochemical properties and spectral data.Results Twelve compounds were isolated from the plant. Their structures were identified as ilexoside D(1), ilexgenin A(2), spinasterol(3), (+)-fraxiresinol-1-O-β-D-glucoside (4), liriodendrin (5), tortoside A(6), magnolenin C(7), syningin(8), sinapic aldehyde 4-O-β-D-glucopyrano- side(9), 4,5-di-O-caffeoylquinic acid(10), β-sitosterol(11) and β-daucosterol(12), respectively. Conclusion Compounds 3, 4 and 10 were isolated from this plant for the first time.
Keywords:Aquifoliaceae  Ilex pubescens  Chemical constituents  Saponin
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