| 卵巢癌微卫星不稳定性的初步研究 |
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| 引用本文： | 傅芬,李里香,张玮,卢寨娥.卵巢癌微卫星不稳定性的初步研究[J].实用癌症杂志,2004,19(5):494-495. |
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| 作者姓名： | 傅芬 李里香 张玮 卢寨娥 |
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| 作者单位： | 330006,江西医学院第二附属医院 |
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| 摘 要： | 目的 探讨卵巢癌是否存在微卫星DNA不稳定性及与其发生的关系。方法 应用PCR 聚丙烯酰胺凝胶电泳 硝酸银染色技术 ,检测 5 1例卵巢癌 3个位点的微卫星不稳定性。结果 3个位点微卫星DNA不稳定性发生率分别为 3 5 .3 % ,41.2 % ,41.2 %。结论 微卫星DNA的不稳定性可能与卵巢癌的发生有关。
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| 关 键 词： | 卵巢癌 微卫星 微卫星不稳定性 |
| 文章编号： | 1001-5930(2004)05-0494-02 |
| 修稿时间： | 2004年7月2日 |
Primary Study of Microsatellite Instability in Ovarian Cancer |
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| FU Fen,LI Li-xiang,ZHANG Wei,et al..Primary Study of Microsatellite Instability in Ovarian Cancer[J].The Practical Journal of Cancer,2004,19(5):494-495. |
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| Authors: | FU Fen LI Li-xiang ZHANG Wei |
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| Institution: | FU Fen,LI Li-xiang,ZHANG Wei,et al. The Second Affiliated Hospital of Jiangxi Medical College,Nanchang,330006 |
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| Abstract: | Objective To detect the microsatellite DNA instability in ovarian cancer and its relationship with the carcinogenesis of ovarian cancer.Methods Microsatellite DNA instability in three different loci in 35 patients with ovarian cancer were screened by ploymerase chain reaction-ployacrylamide gel-silver stain method.Results The incidence of microsatellite instability in these three loci were 35.3%,41.2%,and 41.2%,respectively.Conclusion Microsatellite DNA instability may be related to the carcinogenesis of ovarian cancer. |
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| Keywords: | Ovarian cancer Microsatellite Microsatellite instability(MSI) |
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