代谢综合征(MS)与前列腺癌:分子机制及治疗方法研究进展

 代谢综合征(metabolic syndrome,MS)及其多种组分(肥胖、糖尿病、高血压、高脂血症等)与前列腺癌相关,两者间的分子生物学机制存在复杂的网络联系。本文就MS与前列腺癌发生与进展的流行病学及基础研究文献进行综述,重点阐述MS影响前列腺癌发生发展的分子生物学机制,包括细胞因子、胰岛素与胰岛素样生长因子(insulin like growth factor,IGF)、性激素、炎症与免疫系统、脂肪酸与氨基酸代谢等方面。随后从加强一级预防、拓展经典药物适应证、研发针对靶点的新型药物等角度对防治方法进行梳理和展望。

Metabolic syndrome (MS) and prostate cancer:recent progress in molecular mechanisms and treatments

Metabolic syndrome (MS) and its components (including obesity,diabetes mellitus,hypertension,hyperlipidemia,etc.) were closely associated with prostate cancer.There was a complex biological network connecting MS and the carcinogenesis of prostate cancer.The present review summarized the related epidemiologic and fundamental researches about the relationship between MS and prostate cancer,highlighting several molecular mechanisms involving in cytokines,insulin and insulin like growth factor (IGF),hormones,inflammation and immune systems,fatty acid and amino acid metabolisms.Then several strategies such as enhancing primary prevention,broadening the indications of classic medications and inventing new drugs targeting novel molecules were also discussed.