| 羧乙基锗倍半氧化物对大鼠心肌缺血再灌注损伤的保护作用 |
| |
| 引用本文： | 但汉雄,吴基良,李立中,胡宗礼,明章银,刘忠民,何丽娅. 羧乙基锗倍半氧化物对大鼠心肌缺血再灌注损伤的保护作用[J]. 微量元素与健康研究, 1999, 0(2) |
| |
| 作者姓名： | 但汉雄 吴基良 李立中 胡宗礼 明章银 刘忠民 何丽娅 |
| |
| 作者单位： | 湖北咸宁医学院 |
| |
| 摘 要： | 目的：观察羧乙基锗倍半氧化物（ＣＧＳ）对大鼠实验性心肌缺血再灌注损伤的影响。方法：采用结扎大鼠冠状动脉３０ｍｉｎ后再通６０ｍｉｎ造成心肌缺血再灌注损伤模型，测定动脉血压，心律失常发生率，心律失常严重指数（ＡＳＩ），心肌组织中丙二醛（ＭＤＡ）含量，超氧化物歧化酶（ＳＯＤ）及ＡＴＰａｓｅ活性，血清中乳酸脱氢酶（ＬＤＨ）的水平等指标。结果：预防性静注ＣＧＳ（５０ｍｇ／ｋｇ）可显著降低再灌注心律失常发生率，心肌组织中ＭＤＡ和血清中ＬＤＨ的水平；明显改善再灌注后动脉血压的下降，心肌组织中ＳＯＤ及ＡＴＰａｓｅ活性的降低。结论：ＣＧＳ对大鼠实验性心肌缺血再灌注损伤具有保护作用
|
| 关 键 词： | 有机锗（CGS） 心肌缺血 再灌注损伤 |
The protective effects of carboxyethyl-germanium sesquioxide on myocardial ischemia-reperfusion injury in rats |
| |
| Dan HanxiongWu JiliangLi Lizhonget al. The protective effects of carboxyethyl-germanium sesquioxide on myocardial ischemia-reperfusion injury in rats[J]. Studies of Trace Elements and Health, 1999, 0(2) |
| |
| Authors: | Dan HanxiongWu JiliangLi Lizhonget al |
| |
| Affiliation: | Hu Bei Xianning Medical CollegeXianning437100 |
| |
| Abstract: | OBJECTIVE:In order to observe the effects of carboxyethl-germanium sesquioxide (CGS) on myocardial ischemia-reperfusion.METHODS:the expermental model was established by ligaturing coronary artery for 30 minutes followed by reperfusing for 60 minutesin the rats.The artery blood pressure,rate of reperfusion arrhythmias,arrhythmias severity index (ASI),level of malonaldehyde (MDA),activity of superoxide dismutase(SOD)and ATPase in myocardium,and level of lactate dehydrogenase(LDH) in serum were measured.RESULTS:CGS(50 mg/kg,iv)significantly decreased reperfusion arrhythmias and ASI,inhibited fail of myocardial function,decreased level of MDA and improved activity of SOD in myocardium,and decreased LDH level in serum after reperfusion.CONCLUSION:CGS might have a protective effect on the damage of myocardial ischemia-reperfusion in rats. |
| |
| Keywords: | Carboxyethyl-germanium sesquioxide (CGS)Myocardial ischemiaReperfusion injury |
| 本文献已被 CNKI 等数据库收录！ |
