冠心病患者实施同型半胱氨酸检测的临床意义

目的：探讨同型半胱氨酸浓度水平的检测对于早期诊断急性心肌梗死的应用价值。方法选择2013年1月～2013年12月确诊为冠心病的患者53例为试验组，选择同期进行体检且结果显示为健康的50例为对照组，试验组和对照组均进行同型半胱氨酸、肌酸激酶、肌酸激酶同工酶的测定，对结果进行综合分析。结果试验组的患者血清同型半胱氨酸、肌酸激酶、肌酸激酶同工酶的浓度水平较对照组均有明显上升趋势，差异有统计学意义（P＜0.05）；阳性检出率分析，试验组患者的的同型半胱氨酸、肌酸激酶和肌酸激酶同工酶的检测结果阳性率分别为84.91%（45/53）、81.13%（43/53）、83.02%（44/53），同型半胱氨酸检测结果阳性率分别与肌酸激酶、肌酸激酶同工酶两两比较，差异无统计学意义（P＞0.05）；临床标本相关性分析，同型半胱氨酸检测结果和临床诊断结果的相关性好，Kappa值等于0.81。结论同型半胱氨酸是一种辅助诊断冠心病的有效指标，具有较好的灵敏度和临床符合性。

Clinical significance of the Homocysteine testing in the Coronary atherosclerotic heart disease

Objective To explore the clinical significance of the Homocysteine testing in the Coronary atherosclerotic heart disease . Methods Choosing53 cases of patients with the Coronary atherosclerotic heart disease for the experimental group, and 50 cases of healthy check-up for the control group, testingthe Homocysteine, Creatine Kinase and MB Iso Enzyme of Creatine Kinase, analyze the results comprehensively. Results Compared with the control group,there were significantly higher of the experimental group of the Homocysteine, Creatine Kinase and MB Iso Enzyme of Creatine Kinase results（P 〈 0.05）.The positive rate of the Homocysteine, Creatine Kinase and MB Iso Enzyme of Creatine Kinase was 84.91%, 81.13%, 83.02%, but there were no significantlydifference between the Homocysteine and Creatine Kinase or Homocysteine and MB Iso Enzyme of Creatine Kinase（P 〉 0.05）. Clinical specimenscorrelation analysis results show that the Homocysteine and the correlation of clinical diagnosis result is good（Kappa = 0.81）. Conclusion There is a goodindicators for the Coronary atherosclerotic heart disease diagnosis of the Homocysteine, which has good positive rate and clinical compliance.