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| 五氧化二钒对大鼠肾脏毒性的机理 | |
| 引用本文： | 张瑾岗 仲来福. 五氧化二钒对大鼠肾脏毒性的机理[J]. 中华劳动卫生职业病杂志, 1990, 8(2): 70-74 |
| 作者姓名： | 张瑾岗 仲来福 |
| 作者单位： | 大连医学院(张瑾岗，仲来福)，大连医学院(夏元洵) |
| 摘 要： | 本文用硫代巴比妥酸法(TBA)和DPH 荧光偏振技术探讨了V_2O_5对大鼠肾脏毒性的机理。结果表明V_2O_5在体内、外均能诱发大鼠肾皮质细胞生物糢的脂质过氧化和降低膜脂流动性,并呈现明显的时间-效应和剂量-效应关系。体外染毒后的作用部位主要在线粒体和微粒体,而体内染毒后,主要限于微粒体。醋酸锌和EDTA 在体外实验中能抑制V_2O_5所诱发的脂质过氧化和膜脂流动性的改变。结果还提示,膜脂过氧化与膜脂流动性之间存在依赖关系。 |
| 关 键 词： | 五氧化二钒 肾脏 脂质过氧化 膜流动性 |
Investigation on the Mechanisms of Nephrotoxicity of Vanadium Pentoxide in Rats |
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| Zhang Jin-gang,et al. Investigation on the Mechanisms of Nephrotoxicity of Vanadium Pentoxide in Rats[J]. Chinese journal of industrial hygiene and occupational diseases, 1990, 8(2): 70-74 | |
| Authors: | Zhang Jin-gang et al |
| Abstract: | In this study the mechanisms of nephrotoxicity of V_2O_5were investi-gated with TBA and DPH fluorscence polarization.The results showedthat V_2O_5was able to induce lipid peroxidaton and decrease membrane fl-uidity in biological membrane of renal cortex in rats,chiefly affecting those or mitochondria and microsomes in vitro and merely those ofmicrosomes in vivo,both showed significant dose-dependent and timedependent relationships.Zinc acctatc and EDTA displayed separately invitro,the capability of inhibiting V_2O_5-induced lipid peroxidation andchanges in membrane fluidity.These results suggested that there existdependent relationship between lipid peroxidation and membrane fluidity. |
| Keywords: | Vanadium Pentoxide Kidney Lipid Peroxidation Membrane Fluidity |
| 本文献已被 CNKI 维普 等数据库收录！ | |