| 盔状黄芩中的新克罗烷型二萜化合物 |
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| 引用本文： | 肖凯,张雷,韩庆通,戴胜军. 盔状黄芩中的新克罗烷型二萜化合物[J]. 中国中药杂志, 2016, 41(18): 3366-3370 |
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| 作者姓名： | 肖凯 张雷 韩庆通 戴胜军 |
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| 作者单位： | 烟台大学 药学院, 山东 烟台 264005,烟台大学 药学院, 山东 烟台 264005,烟台大学 药学院, 山东 烟台 264005,烟台大学 药学院, 山东 烟台 264005 |
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| 基金项目： | 国家自然科学基金项目（21372189）；山东省自然科学基金项目（ZR2013HM023） |
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| 摘 要： | 应用硅胶柱色谱、Sephadex LH-20柱色谱及高效制备薄层等方法对盔状黄芩中的二萜单体进行分离纯化,根据理化性质和波谱数据对其化学结构进行解析,发现并鉴定了14个新克罗烷型二萜,分别为半枝莲碱D(1),scutolide A(2),scutolide K(3),scutebata J(4),scutebata I(5),6-乙酰氧基河南半枝莲碱A(6),半枝莲素C(7),scutolide E(8),barbatine C(9),半枝莲碱Y(10),半枝莲碱B(11),scutestrigillosin A(12),scutebata O(13),scutolide B(14)。化合物1~14均为首次从盔状黄芩中发现。
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| 关 键 词： | 唇形科 黄芩属 盔状黄芩 新克罗烷型二萜 |
| 收稿时间： | 2016-04-26 |
neo-Clerodane diterpenoids from Scutellaria galericulata |
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| XIAO Kai,ZHANG Lei,HAN Qing-tong and DAI Sheng-jun. neo-Clerodane diterpenoids from Scutellaria galericulata[J]. China Journal of Chinese Materia Medica, 2016, 41(18): 3366-3370 |
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| Authors: | XIAO Kai ZHANG Lei HAN Qing-tong DAI Sheng-jun |
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| Affiliation: | School of Pharmaceutical Science, Yantai University, Yantai 264005, China,School of Pharmaceutical Science, Yantai University, Yantai 264005, China,School of Pharmaceutical Science, Yantai University, Yantai 264005, China and School of Pharmaceutical Science, Yantai University, Yantai 264005, China |
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| Abstract: | By means of preparative HPTLC and column chromatography over silica gel and Sephadex LH-20, fourteen diterpenoids were isolated and purified from the whole plants of Scutellaria galericulata. Based on the physico-chemical properties and spectral data, their structures were elucidated and identified as:scutebarbatine D(1), scutolide A(2), scutolide K(3), scutebata J(4), scutebata I(5), 6-O-acetylscutehenanine A(6), barbatin C(7), scutolide E(8), barbatine C(9), scutebarbatine Y(10), scutebarbatine B(11), scutestrigillosin A(12), scutebata O(13), scutolide B(14). Compounds 1-14 were isolated from S. galericulata for the first time. |
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| Keywords: | Lamiaceae Scutellaria Scutellaria galericulata neo-clerodane diterpenoid |
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