| 丹参酚酸类成分生物合成途径及调控机制研究进展 |
| |
| 引用本文： | 曾慧婷,宿树兰,朱悦,谷巍,钱大玮,段金廒.丹参酚酸类成分生物合成途径及调控机制研究进展[J].中草药,2016,47(18):3324-3331. |
| |
| 作者姓名： | 曾慧婷 宿树兰 朱悦 谷巍 钱大玮 段金廒 |
| |
| 作者单位： | 南京中医药大学 江苏省中药资源产业化过程协同创新中心 中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏 南京 210023;南京中医药大学 江苏省中药资源产业化过程协同创新中心 中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏 南京 210023;南京中医药大学 江苏省中药资源产业化过程协同创新中心 中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏 南京 210023;南京中医药大学 江苏省中药资源产业化过程协同创新中心 中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏 南京 210023;南京中医药大学 江苏省中药资源产业化过程协同创新中心 中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏 南京 210023;南京中医药大学 江苏省中药资源产业化过程协同创新中心 中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏 南京 210023 |
| |
| 基金项目： | 江苏省“333高层次人次培养工程”资助项目（BRA2015391） |
| |
| 摘 要： | 丹参酚酸类成分为丹参治疗心脑血管疾病的主要有效成分,具有显著而确切的生物活性和药理作用。随着临床及市场对丹参酚酸类物质需求量的剧增,提高丹参中酚酸类成分的量及提升利用效率对其可持续发展具有重要意义。基于丹参基因组学、转录组学及代谢组学等方面近年来的研究进展,对丹参酚酸类成分的生物合成途径、关键酶基因与调控机制,以及丹参酚酸类成分生物转化利用现状等进行归纳分析,以期为丹参酚酸类物质资源的高效生产与资源综合利用提供科学依据。
|
| 关 键 词： | 丹参 酚酸类成分 关键酶基因 生物合成途径 调控机制 |
| 收稿时间： | 2016/3/18 0:00:00 |
Research process in biosynthesis pathway and regulation mechanism of phenolic acids in roots and rhizomes of Salvia miltiorrhiza |
| |
| ZENG Hui-ting,SU Shu-lan,ZHU Yue,GU Wei,QIAN Da-wei and DUAN Jin-ao.Research process in biosynthesis pathway and regulation mechanism of phenolic acids in roots and rhizomes of Salvia miltiorrhiza[J].Chinese Traditional and Herbal Drugs,2016,47(18):3324-3331. |
| |
| Authors: | ZENG Hui-ting SU Shu-lan ZHU Yue GU Wei QIAN Da-wei and DUAN Jin-ao |
| |
| Institution: | Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China |
| |
| Abstract: | Phenolic acids with significant biological activity and pharmacological effects are a class of active ingredients in the roots and rhizomes of Salvia miltiorrhiza used for the treatment of cardiovascular and cerebrovascular diseases.With increasing the demand of clinical and market,enhancing the contents and utilization efficiency of phenolic acids in the roots and rhizomes of S.miltiorrhiza has the important practical significance for sustainable development.In this paper,the research progress in study on genomics,proteomics,and metabonomics in recent years was carried out to summarize the biosynthesis pathway,key enzymes genes,regulation mechanism,and bioconversion and utilization of phenolic acids in the roots and rhizomes of S.miltiorrhiza,which lays the scientific foundation for the efficient production and comprehensive utilization of phenolic acids resources in S.miltiorrhiza. |
| |
| Keywords: | roots and rhizomes of Salvia mltiorrhiza phenolic acids gene of key enzyme biosynthesis pathway regulation mechanism |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中草药》浏览原始摘要信息 |
| 点击此处可从《中草药》下载免费的PDF全文 |
|
