高良姜提取物对2型糖尿病小鼠的降糖作用

目的：研究高良姜提取物对2型糖尿病小鼠的降糖作用。方法采用高脂高糖饮食加小剂量链脲佐霉素(STZ)注射诱导2型糖尿病小鼠模型，饲养过程中动态监测小鼠的血糖水平、体质量变化，待小鼠血糖水平达到实验要求后，以高良姜提取物稀释不同倍数、二甲双胍、生理盐水灌胃。30 d后测定小鼠的空腹血糖、糖耐量等指标，并观察小鼠肝组织病理切片。结果高脂高糖饲料饲喂联合小剂量注射STZ诱导的2型糖尿病小鼠，高良姜提取物能显著降低糖耐量试验2 h血糖浓度(P<0.05)，对体质量也具有一定的调节作用(P<0.05)，50 mg/kg剂量组在给药后空腹血糖表现出显著改善(P<0.05)，但对肝损伤、脂肪性病变无明显改善作用。结论高良姜提取物对糖尿病小鼠的血糖水平有一定的降糖作用。

Hypoglycemic effects of the extracts of Alpinia officinarum Hance on type 2 diabetic model mice

Objective To study the hypoglycemic effects of extracts of Alpinia officinarum Hance (galangal) on type 2 diabetic model mice. Methods Streptozocin (STZ) and high fat and high-sugar diet were used to induce type 2 diabetes in mice. The glucose levels, body weight, and food intaking in feeding process were observed. After the blood sugar levels in mice reaching tested requirements, galangal extract, metformin, and normal saline were orally given to mice. After 30 days, the fasting blood glucose, pathological section, and other factors were investigated. Results Ad-ministrating galangal extract to mice led to a significant decrease in their 2 h blood glucose concentration after a glucose tolerance test (P<0.05), which also had a regulative effect on body weight (P<0.05). In the group of 50 mg/kg galangal extract, significant improvement was observed in the fasting blood glucose (P<0.05), but no significant improvement was found in the recovery of liver damage and fatty degeneration. Conclusion The galangal extract has hypoglycemic effects on the blood sugar in type 2 diabetic model mice.