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| 小分子RNA-9对上皮细胞钙黏蛋白表达调控的研究进展 | |
| 引用本文： | 肖建华,董自强,游艳. 小分子RNA-9对上皮细胞钙黏蛋白表达调控的研究进展[J]. 海南医学, 2016, 0(7): 1135-1137. DOI: 10.3969/j.issn.1003-6350.2016.07.036 |
| 作者姓名： | 肖建华 董自强 游艳 |
| 作者单位： | 1. 三峡大学第一临床医学院泌尿外科三峡大学泌尿外科研究所,湖北 宜昌,443003;2. 三峡大学仁和医院,湖北 宜昌,443000 |
| 摘 要： | 上皮细胞钙黏蛋白(E-cadherin)参与多种正常细胞或肿瘤细胞的功能活动,而其自身的表达水平又受小分子RNA(miRNA)等多种因素的调节,使得miRNA-E-cadherin通路在多种疾病中的重要作用受到了广泛关注.本文就目前发现的miRNA-9在不同肿瘤疾病或非肿瘤疾病发生和发展过程中对E-cadherin表达的调控情况作一综述. |
| 关 键 词： | 上皮细胞钙黏蛋白 miRNA 肿瘤 调控 |
Research progress of the regulation of small molecule RNA-9 to epithelial cell calcium sticky protein |
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| Abstract: | Epithelial cell calcium sticky protein (E-cadherin) is involved in the functional activities of many nor-mal cells and tumor cells. Its expression level is regulated by microRNAs (miRNA) and other factors, which makes the important roles of miRNA-E-cadherin signaling pathway in variety of diseases have been widely concerned. In this pa-per, the regulation of miRNA-9 to expression of E-cadherin in different tumor diseases, non-cancer diseases or during tu-mor progression were reviewed. |
| Keywords: | E-cadherin miRNA Tumor Regulation |
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