| 2型糖尿病性血管病和红细胞膜Na+*K+-ATP酶活性 |
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| 引用本文： | 何浩明,黄慧建,徐宁,李小民,田小平,汪洪流. 2型糖尿病性血管病和红细胞膜Na+*K+-ATP酶活性[J]. 蚌埠医学院学报, 2001, 26(4) |
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| 作者姓名： | 何浩明 黄慧建 徐宁 李小民 田小平 汪洪流 |
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| 作者单位： | 1. 江苏省连云港市第一人民医院临床内分泌研究室,
2. 江苏省连云港市东方医院内分泌科, |
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| 基金项目： | 江苏省连云港市科技局科研项目 |
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| 摘 要： | 目的 :探讨 2型糖尿病性血管病患者的红细胞膜Na+·K+ ATP酶活性的变化及其意义。方法 :按Reilini制膜法测定5 5例 2型糖尿病性血管病红细胞膜Na+·K+ ATP酶活性 ,并与 35名健康组作对照 ,并且将其结果与红细胞内Na+·K+浓度、空腹血糖、糖化血红蛋白等进行相关分析。结果 :2型糖尿病血管病患者红细胞膜Na+·K+ ATP酶含量显著低于正常人(P <0 .0 1) ,且与红细胞内Na+·K+浓度、空腹血糖、糖化血红蛋白等密切相关。结论 :红细胞膜Na+·K+ ATP酶活性的下降可能参与糖尿病性血管病变的发生、发展过程
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| 关 键 词： | 糖尿病性血管病 红细胞膜 酶激活 |
Na+*K+-ATPase activity of erythrocyte membrane in diabetic type 2 angiopathies |
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| HE Hao-ming,WANG Hong-liu,HUANG Hui-jian,XU Ning,LI Xiao-min,TIAN Xiao-ping. Na+*K+-ATPase activity of erythrocyte membrane in diabetic type 2 angiopathies[J]. Journal of Bengbu Medical College, 2001, 26(4) |
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| Authors: | HE Hao-ming WANG Hong-liu HUANG Hui-jian XU Ning LI Xiao-min TIAN Xiao-ping |
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| Abstract: | Objective:To study on the change of Na+*K +-ATPase activity of erythrocyte membrane of patients with diabetic type 2 an giopathies.Methods:According to Reilini method the concentrations of erythrocyt e membrane Na+*K+-ATPase of 55 cases with diabetic type 2 angiopathies and 35 normal controls were measured.With density of Na+ and K+,levels of f asting blood glucose(FBG),glycosylated hemoglobin(GHb) were also detected.Results:Na+*K+-ATPase activity of erythrocyte membrane was sig nificantly decreased in diabetic type 2 patients(P＜0.01).Conclusions:Decreased Na+*K+-ATPase activity in erythrocyte me mbrane may be one of factors that contributed to the occurrence and development of diabetic type 2 mellitus. |
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| Keywords: | diabetic angiopathies erythrocyte membrane enzyme activation |
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