磷脂酰胆碱对小鼠记忆障碍模型的影响

[目的]探讨磷脂酰胆碱(PC)对小鼠学习记忆过程三环节整合调节作用,为"PC是健脑食物"提供进一步实验室依据。[方法]设PC对小鼠记忆获得障碍、记忆巩固障碍、记忆再现障碍的改善作用3大组。每大组设4小组,包括模型对照组、磷脂酰胆碱3个剂量组(0.1g/kg.bw、0.2g/kg.bw、0.3g/kg.bw),每小组10只小鼠。实验期末对3大组分别进行跳台试验、避暗试验和水迷宫试验。[结果]记忆获得障碍实验中,学习试验时各剂量组的错误次数明显减少,消退试验时各剂量组的错误次数明显减少,潜伏期明显延长;记忆巩固障碍实验中,测验时各剂量组的潜伏期明显延长,消退试验时各剂量组的潜伏期明显延长、错误次数显著减少,0.3g/kg.bw组的错误动物百分率明显减少;记忆再现障碍实验中,消退试验时各剂量组的错误次数明显减少,且各剂量组到达终点的时间明显缩短。[结论]PC明显提高学习记忆过程三环节障碍小鼠的学习记忆能力,具有整合改善记忆效能的作用。

EFFECT OF PHOSPHATIDYL CHOLINE (PC) ON MICE MODEL OF DYSMNESIA

[Objective] To study effect of phosphatidyl choline (PC) on mice model of dysmnesia and provide scientific basis for health products. [Methods] Three mice model were established, including mice memory-obtaining obstacles model group, mice memory-consolidating obstacles model group and mice memory-reappearing obstacles model group. Every model group was composed of four subgroups (n=10): model control group and three experiment groups (0.1g/kg.bw, 0.2g/kg.bw, 0.3g/kg.bw). Finally, carried out step down test,...