高脂血症时羟脯氨酸代谢与动脉粥样硬化关系的初探

本文通过动态检测食饵性高脂血症兔血清总胆固醇(TC)、羟脯氨酸(HYP)及血浆钙、铜浓度发现:HYP、钙、铜浓度与TC变化一致,即随喂高脂饲料时间的延长而明显增高。其中HYP、钙浓度与TC水平变化呈显著正相关。同时还发现,喂高脂饲料60天后停喂高脂饲料60天,血清TC水平迅速降至接近正常水平,而HYP含量则下降至显著低于同期对照组的水平(P<0.01和0.001)。停喂高脂饲料180天时血清TC、HYP均恢复至对照组水平。形态观察发现,动脉壁胶原纤维明显增多。结果表明,高胆固醇血症明显影响胶原代谢,这些变化可能与血钙、铜浓度的变化有关。

EXPERIMENTAL STUDY ON THE RELATION BETWEEN HYDROXYPROLIN METABOLISM ANDATHEROSCLEROSIS IN HYPERLIPIDEMIC RABBIT

Dynamic changes of the concentration of serum total cholesterol (TC), hydroxyproline (HYP), Ca~(2 ) and Cu~(2 ) were studied in serum of dietindueed hyperlipidemic rabbits.All of the parameters were increased, the longer the time of high fat diet the more the increase of the parameters. There was a linear positive correlation between HYP and TC. Serum TC of hyperlipidemic rabbits decreased to the level of controls after changing to normal diet for 60 days, while HYP level fell down more rapidly to a level lower than control and became normal not until 180 clays of normal diet. Morphological study revealed that collagen fibers in the arterial wall increased significantly. It indicates that HYP in the serum had been utilized to synthesize collagen by the proliferating smooth muscle ceils in AS lesions. The results suggest that hyperlipidemia affects significantly on collagen metabolism which might be related to the change of Ca~(2 ) and Cu~(2 ) concentrations in the serum.