| 生长因子网络调节对骨形成作用的研究：Ⅴ.不同生长因子交互应用对人？… |
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| 引用本文： | 田卫东.生长因子网络调节对骨形成作用的研究：Ⅴ.不同生长因子交互应用对人？…[J].华西口腔医学杂志,1999,17(1):78-81. |
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| 作者姓名： | 田卫东 |
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| 作者单位： | 华西医科大学口腔医学院 |
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| 基金项目： | 高等学校博士学科点专项科研项目，CMBY-9401， |
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| 摘 要： | 考察将转化生分子β、胰岛素样生长因子Ⅱ、碱性成纤维细胞生长因子及血小板衍生长性生和茵子４种生长因子两两交互应用对人胚成骨样细胞增殖与分化的影响。方法：在不同的实验间期检测成骨样细胞＾３Ｈ－胸腺嘧啶脱氧苷、＾３Ｈ－脯氨酸的掺入量和碱性磷酸酶的含量。
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| 关 键 词： | 生长因子 成骨细胞 细胞增殖 细胞分化 |
Effects of Two Growth Factors Combination on the Proliferation and Differentiation of Human Osteoblast-like Cells |
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| Tian Weidong, Wang Dazhang, Qiao
Ju, et al
College of Stomatology, West China University Medical Sciences.Effects of Two Growth Factors Combination on the Proliferation and Differentiation of Human Osteoblast-like Cells[J].West China Journal of Stomatology,1999,17(1):78-81. |
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| Authors: | Tian Weidong Wang Dazhang Qiao
Ju College of Stomatology West China University Medical Sciences |
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| Institution: | College of Stomatology, West China University Medical Sciences. |
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| Abstract: | OBJECTIVE: To examine the effects of platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF), insulin-like growth factor (IGF-II) and type beta transforming growth factor(TGF-beta) which were believed to have biological effects on bone cells on human osteoblast-like cells. METHODS: 3H-TdR, 3H-Proline and alkaline phosphatase of the osteoblast-like cells were tested to study the combinating effects of different growth factors on the proliferation and differentiation of osteoblast-like cells. RESULTS: The combination of different growth factors had promotive effect and synergic interact on proliferation and differentiation of osteoblast-like cells. CONCLUSION: The phenomena indicate that the combination of two growth factors will enhance the biological effects of bone formation. |
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