异时性结直肠癌肝转移及其治疗

结直肠肿瘤原发病灶切除术后>6个月出现的肝脏转移称之为异时性肝转移。本文就目前对异时性肝转移的国外研究进行总结和分析:肿瘤细胞可能在术前、术中及术后转移到肝脏;原发灶为TNMⅢ期、肿瘤大小>3 cm、浸润溃疡型病灶为危险因素;异时性肝转移患者的总体生存率优于同时性肝转移;肿瘤的大小与数目是主要决定预后的不良因素;手术是目前最有效的治疗手段,新辅助化疗有助于提高切除率,射频消融是治疗不可切除病灶的首选方法。

Metachronous Metastases of Colorectal Cancer

Metachronous metastatic disease was defined as liver metastasis presenting at six months after the resection of the primary colorectal tumor. This article summarized the eurrentl research of metaehronous liver metastasis abroad, and deduced that the tumor cells may shift to liver before, during and after resection for colorectal cancer. TNM stage of primary tumor, tumor size, ulceroin？ Itrating type were independently risk of metachronous liver metastasis. The overall survival rates of the patients with metachronous metastases were better than those with synchronous metastases and the tumor size and number were adverse prognosis factors. Surgery is the most effective methods up to now, Neoadjuvant chemotherapy contribute to the increased resection rate, radiofrequency ablation was the first method for treatment of tumor without being resection.