熊去氧胆酸对胆肠吻合术后胆道逆行性感染的预防作用

目的：探讨熊去氧胆酸(UDCA)对胆肠吻合术后胆道逆行性感染的预防作用。 方法：将2年间收治的50例接受胆肠吻合术的患者随机分为对照组和观察组。除传统的胆肠吻合术后处理外，对照组于术后给予维生素C，而观察组则给予UDCA。比较两组术后胆道逆行性感染的发生率。所有患者术后随访6个月至2年。结果：观察组术后胆道逆行感染的发生率较对照组显著降低(4.0%vs.32.0%)（P＜0.05）。 结论：胆肠吻合术后应用UDCA安全，可显著降低术后胆道逆行感染的发生率。

The effect of ursodeoxycholic acid on prevention of retrograde biliary tract infection after cholangioenterostomy

ObjectiveTo investigate the effect of ursodeoxycholic acid（UDCA） on prevention of retrograde biliary tract infection after cholangioenterostomy. MethodsFifty patients undergoing cholecystojejunostomy,cholangio-jejunostomy, pancreaticoduodenectomy and choledochoduodenostomy treated in our hospital, during a 2-year period, were randomly divided into control group and observation group, respectively. In addition to conventional postoperative care, control group received vitamin C, while UDCA was given to observation group. The incidence of postoperative retrograde infection of biliary tract in the two groups was compared. The duration of follow-up varied from 6 months to 2 years. ResultsCompared with control group, The incidence of postoperative retrograde biliary tract infection in therapy group was significantly lower than that in comtrol group (4.0%vs.32.0%)(P＜0.05). ConclusionsAdministration of UDCA following cholangioenterostomy is safe, and it can significantly reduce the occurrence rate of retrograde biliary tract infection.