508例女性人乳头瘤病毒感染及相关因素分析

目的探讨人乳头瘤病毒(HPV)感染现状及感染相关因素,为预防和控制HPV感染提供理论依据。方法选取2009年1月至2010年12月于本院妇科门诊就诊的508例自愿接受宫颈HPV检查者为研究对象,取其宫颈脱落细胞标本,采用快速导流杂交技术HPVDNA检测法进行HPV基因型分型。并采用多因素Logistic回归模型分析,探讨HPV感染的相关因素,包括年龄、文化程度、初次性生活年龄、流产次数、性伴侣数、配偶伴侣数、吸烟史及避孕方式等(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准,得到该委员会批准,征得受试对象的知情同意)。结果本组508例受试者HPV总感染率为22.05%(112/508),其中高危型HPV(HR-HPV)感染率为18.90%(95/508),低危型HPV(LR-HPV)感染率为2.17%(11/508),中国人常见感染基因型为1.18%%(6/508)。508例受试者中,感染率最高的5种HPV基因型分别为HPV-16(7.68%)-52(4.72%),-58(3.74%),-18(3.15%),-31(2.36%)。影响HPV感染的相关因素为:初次性生活年龄、性伴侣数、配偶性伴侣数、流产次数及吸烟史(χ2=105.539,5.092,37.158,5.076,13.824;P<0.05),进一步行多因素非条件Logistic回归分析显示,初次性生活年龄(OR=13.036)、性伴侣数(OR=5.860)、配偶性伴侣数(OR=2.120)、吸烟史(OR=2.054)为影响HPV感染的独立危险因素(P<0.05)。结论不良的生活习惯及性行为是女性HPV感染的高危因素,改变不良生活习惯及性行为是预防HPV感染的有效手段。

Analysis of Human Papillomavirus Infection and Its Related Factors Among 508 Women

Objective To investigate prevalence , genotypes distribution and related infection factors of human papillomavirus ( HPV ) in order to provide scientific evidence for the prevention and control of HPV infection.Methods From January 2009to December 2010 , a total of 508women who received cervical HPV testing in Second Affiliated Hospital of Qingdao University Medical College were included into this study.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Second Affiliated Hospital of Qingdao University Medical College.After obtaining specimens of cervical cytology , rapid flow-through hybridization technique ( namely Hybribio flow-through hybridization ) was used to detect HPV genotypes simultaneously.Multiple factors non-conditional logistic regression analytic method was used to discuss the relationship between HPV infection and related factors ( age , educational level , initial age for sex , number of pregnancy termination , number of sexual partners , number of spouse′s sexual partners , smoking history and contraception measures ) .Results Among 508women received HPV infection test , the total HPV infection rate was 22.05% ( 112 / 508 ), including the high-risk HPV ( HR- HPV ) subtypes infection rate was 18.90% ( 95 / 508 ), the low-risk HPV ( LR-HPV ) subtypes infection rate was 2.17% ( 11 / 508 ), the most common type of Chinese was 1.18% ( 6 / 508 ) .The top five high-risk subtypes were HPV-16 ( 7.68% ), -52 ( 4.72% ), -58 ( 3.74% ), -18 ( 3.15% ), -31 ( 2.36% ) .The relative factors of HPV infection in 508 women were initial age for sex , number of sexual partners , number of spouse′s sexual partners , number of pregnancy termination and smoking history ( χ 2 =105.539 , 5.092 , 37.158 , 5.076 , 13.824 , respectively , P<0.05 ) .Multiple factor non-conditional Logistic regression model analysis showed that the independent factors were initial age for sex ( OR=13.036 ), number of sexual partners ( OR=5.860 ), number of spouse′s sexual partners ( OR=2.120 ), and smoking history ( OR= 2.054 ) .Conclusions The independent risk factors for HPV infection in women are bad living habits and bad sexual behavior.Changing bad living habits and bad sexual behavior are effective ways to prevent HPV infection.