银杏苦内酯B对哮喘豚鼠气道反应性和嗜酸性粒细胞的影响 |
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引用本文: | 李树钧,孙滨.银杏苦内酯B对哮喘豚鼠气道反应性和嗜酸性粒细胞的影响[J].第四军医大学学报,1995,16(4):269-271. |
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作者姓名: | 李树钧 孙滨 |
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作者单位: | 西京医院呼吸内科 |
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摘 要: | 作利用豚鼠哮喘模型观察豚鼠吸入卵蛋白(OA)或血小板激活因子(PAF)后引起的气道反应,血浆和支气管肺泡灌洗液(BALF)中溶血-PAF(Lyso-PAF)含量和肺组织中嗜酸性粒细胞(E0)改变,及PAF拮抗剂银杏苦内酯B(GB)的影响。结果提示致敏豚鼠OA激发和正常豚鼠PAF激发后,与对照组相比,豚鼠血浆和BALF中Lyso-PAF含量增高(P〈0.01),肺组织中E0数增多(P〈0.01),
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关 键 词: | 哮喘 银杏苦内酯B 气道反应性 血小板激活因子 |
The effect of ginkgolide B on airway reactivity and eosinophil in asthmatic guinea pig |
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Abstract: | We have studied the influence of PAF antagonist,ginkgolide B,on the level of Lyso-PAF in
serum and BALF,eosinophil number in the lung tissue from guuinea pig asthmatic models,
provocated with ovalbu-min or PAF.The results revealed that after guinea pigs challenged with
ovalbumin or PAF, compared with control group, Lyso-PAF content in plasma and BALF
increased (P< 0.01 ),pulmonary airway eosinophil number increased(P<0.01),airway
epithelium was injured,airway smooth muscle contracted,airway reac-tivity became
high(P<0.01).If ginkgolide B was given before ovalbumin or PAF challenged,these patho-logic
changes could be inhibited(P<0.01).These demonstrated that ginkgolide B may exert protective
ef-fects on experimental asthma. |
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Keywords: | asthma PAF ginkgolide B |
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