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| 几丁质/rhBMP2/胶原复合物修复骨缺损的实验研究 | |
| 引用本文： | 陈富林,毛天球,王常勇,赵明,王会信. 几丁质/rhBMP2/胶原复合物修复骨缺损的实验研究[J]. 实用口腔医学杂志, 2002, 18(4): 341-343 |
| 作者姓名： | 陈富林 毛天球 王常勇 赵明 王会信 |
| 作者单位： | 1. 西安第四军医大学口腔医学院,710032 2. 军事医学科学院 |
| 摘 要： | 目的：研究几丁质作为骨缺损充填材料和rhBMP2载体的可行性。方法：制备多孔几丁质及几丁质/rhBMP2/胶原复合物，进行了几丁质，几丁质/rhBMP2/胶原复合物修复兔颅骨缺损的实验研究。通过X线片，组织学检查评价其骨缺损修复能力。结果：实验结果表明几丁质具有一定的骨引导活性，与rhBMP2复合后，成为既具有骨引导活性，又具有骨诱导活性的复合植骨材料，具有较强的骨缺损修复能力。结论：几丁质适于作为骨替代材料及BMP的载体，但在材料的强度和表面活性上还需要改进。 |
| 关 键 词： | rhBMP2 实验研究 几丁质 骨形成蛋白 胶原 植骨材料 |
| 文章编号： | 1001-3733(2002)-04-0341-03 |
| 修稿时间： | 2001-02-07 |
Repair of bone defect with chitin/rhBMP2/collagen complex |
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| Chen Fulin,Mao Tianqiu,Wang Changyong,et al.. Repair of bone defect with chitin/rhBMP2/collagen complex[J]. Journal of Practical Stomatology, 2002, 18(4): 341-343 | |
| Authors: | Chen Fulin Mao Tianqiu Wang Changyong et al. |
| Affiliation: | Chen Fulin,Mao Tianqiu,Wang Changyong,et al. College of Stomatology,Fourth Military Medical University,Xi'an 710032 |
| Abstract: | Objective: To investigate the feasibility of chitin as bone substitute material and carrier of rhBMP2.Methods: Porous chitin and chitin/rhBMP2/collagen complex were implanted into calvarial defects in 8 rabbits. Bone repairing ability was assessed by radiographic and histological observation. 2 rabbits without implantation were served as controls. Results: Chitin had certain bone conductive ability. When combined with rhBMP2,a complex possessing both bone conductive activity and bone inductive activity was produced. The complex had greater bone repairing ability than chitin alone. Conclusion: Chitin may be used as a bone substitute material and carrier of BMP. But its mechanical strength and surface activity should be improved. |
| Keywords: | Chitin Bone morphogenetic protein Collagen Bone substitute material |
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