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Dynamic changes and surveillance function of prion protein expression in gastric cancer drug resistance |
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| Authors: | Wang Ji-Heng Du Jing-Ping Zhang Ying-Hai Zhao Xiao-Jun Fan Ru-Ying Wang Zhi-Hong Wu Zi-Tao Han Ying |
| Affiliation: | Ji-Heng Wang,Jing-Ping Du,Xiao-Jun Zhao,Ru-Ying Fan,Zhi-Hong Wang,Zi-Tao Wu,Ying Han,Department of Gastroenterology,Beijing Army General Hospital,Beijing 100700,China Ying-Hai Zhang,Department of General Surgery,Jiamusi University Medical College,Jiamusi 154004,Heilongjiang Province,China |
| Abstract: | AIM:To explore the dynamic changes of prion protein (PrPc) in the process of gastric cancer drug resistance and the role of PrPc expression in the prognosis of gastric cancer patients receiving chemotherapy.METHODS:A series of gastric cancer cell lines resistant to different concentrations of adriamycin was established,and the expression of PrPc,Bcl-2 and Bax was detected in these cells.Apoptosis was determined using Annexin V staining.Western blotting and immunohisto-chemistry were performed to detect the ... |
| Keywords: | Prion protein Gastric cancer Drug resistance Chemotherapy Apoptosis |
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