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Human papillomavirus in upper digestive tract tumors from three countries |
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| Authors: | Castillo Andres Koriyama Chihaya Higashi Michiyo Anwar Muhammad Bukhari Mulazim Hussain Carrascal Edwin Mancilla Lida Okumura Hiroshi Matsumoto Masataka Sugihara Kazumasa Natsugoe Shoji Eizuru Yoshito Akiba Suminori |
| Affiliation: | Andres Castillo,Chihaya Koriyama,Muhammad Anwar,Suminori Akiba,Department of Epidemiology and Preventive Medicine,Kagoshima University Graduate School of Medical and Dental Sciences,Kagoshima 890-8544,Japan Michiyo Higashi,Department of Human Pathology,Japan Mulazim Hussain Bukhari,King Edward Medical University,Lahole 54000,Pakistan Edwin Carrascal,Department of Pathology,Universidad del Valle,Cali 76004... |
| Abstract: | AIM: To clarify human papillomavirus (HPV) involvement in carcinogenesis of the upper digestive tract of virological and pathological analyses. METHODS: The present study examined the presence of HPV in squamous cell carcinomas of the oral cavity (n = 71), and esophagus (n = 166) collected from Japan, Pakistan and Colombia, with different HPV exposure risk and genetic backgrounds. The viral load and physical status of HPV16 and HPV16-E6 variants were examined. Comparison of p53 and p16INK4a expression in HP... |
| Keywords: | Human papillomavirus Viral load Physical status E6 p53 p16INK4a |
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