Increased fibrosis progression rates in hepatitis C patients carrying the prothrombin G20210A mutation |
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| Authors: | Maharshak Nitsan Halfon Philippe Deutsch Varda Peretz Hava Berliner Shlomo Fishman Sigal Zelber-Sagi Shira Rozovski Uri Leshno Moshe Oren Ran |
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| Affiliation: | Department of Gastroenterology and Liver diseases, Tel Aviv Sourasky Medical Center, affiliated to the Sackler School of Medicine, Tel Aviv University, 64239 Tel Aviv, Israel. nitsan_maharshak@walla.com |
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| Abstract: | AIM: To examine whether hepatitis C virus (HCV)-infected patients who carry hypercoagulable mutationssuffer from increased rates of liver fi brosis. METHODS: We analyzed DNA samples of 168 HCV patients for three common hypercoagulable gene mutations: prothrombin 20210 (PT20210), factor V Leiden (FV Leiden) and methylene tetrahydrofolate reductase (MTHFR). The patients were consecutively recruited as part of the prospective Fibroscore Study in France. The effect of the various mutations on the rate of fi-bro... |
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| Keywords: | Hepatitis C virus Liver fi brosis Hyperco-agulation Prothrombin 20210 |
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