分枝杆菌肉芽肿形成的细胞及分子机制究进展

分枝杆菌肉芽肿是由细菌与不同的宿主细胞如巨噬细胞、树突细胞、淋巴细胞等相互作用,在各种免疫分子如细胞因子、黏附分子、补体等参与下,形成的特征性病理学结构.其形成过程中细菌各种成分、宿主不同细胞、产生的不同免疫分子均起重要作用.而斑马鱼模型的建立及原位荧光观察方法的应用亦为分枝杆菌尤其是海鱼分枝杆菌感染肉芽肿的体内形成及演变研究提供基础.

Cellular and molecular mechanisms underlying the formation of mycobacterial granuloma: an update

Mycobacterial granuloma is a specific pathogenic structure formed through the interaction between bacteria and different host cells such as macrophages,dendritic cells and lymphocytes with the involvement of various immune molecules such as cytokines,adhesion molecules,complements,etc.During the process of formation,bacteria,host cells and immune molecules each play indispensable roles.Moreover,the development of zebrafish model and application of fluorescence-based in situ observation technique have provided a basis for the investigation into the in vivo formation and evolution of mycobacterial granuloma especially Mycobacterium marinum granuloma.