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| 一种可生物降解温度敏感型聚乙二醇-聚己内酯-聚乙二醇水凝胶的合成和表征 | |
| 引用本文： | 巩长,顾迎春,谢震,谢希惠,刘彩兵,阚兵,涂铭旌,魏于全,钱志勇. 一种可生物降解温度敏感型聚乙二醇-聚己内酯-聚乙二醇水凝胶的合成和表征[J]. 生物医学工程学杂志, 2008, 25(5) |
| 作者姓名： | 巩长 顾迎春 谢震 谢希惠 刘彩兵 阚兵 涂铭旌 魏于全 钱志勇 |
| 作者单位： | 1. 四川大学,华西医院,肿瘤生物治疗国家重点实验室,成都,610041 2. 四川大学,纺织系,成都,610065 3. 江苏省姜堰市中医院,姜堰,225500 4. 四川大学,材料科学与工程学院,成都,610065 |
| 基金项目： | 四川省科技攻关项目资助课题(06(05SG022-021-02)) |
| 摘 要： | 合成了一系列分子量较低的聚乙二醇．聚己内酯-聚乙二醇（Poly（ethylene glycol）-Polycaprolactone-Poly（ethylene glycol），PEG-PCL—PEG）三嵌段共聚物。分别采用FTIR和1H—NMR对其结构进行了表征。所合成的PEG-PCL-PEG共聚物具有良好的水溶性，当水溶液浓度高于临界凝胶浓度（Critical gel concentration，CGC）时，随着温度的变化聚合物水溶液会呈现特有的凝胶-溶胶转变。研究了共聚物亲水疏水链段的比例和长度，以及热历史等对凝胶-溶胶转变行为的影响。通过调节上述条件，可以在一定程度上拓宽凝胶-溶胶转变温度范围，有助于PEG—PCL-PEG水凝胶在可注射药物控制释放系统等方面的应用。 |
| 关 键 词： | 聚己内酯-聚乙二醇共聚物 可生物降解 温度敏感 水凝胶 |
Synthesis and Characterization of Thermosensitive Hydrogel Based on PEG-PCL-PEG Block Copolymers |
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| Gong Changyang,Gu Yingchun,Xie Zhen,Xie Xihui,Liu Caibing,Kan Bing,Tu Mingjing,Wei Yuquan,Qian Zhiyong. Synthesis and Characterization of Thermosensitive Hydrogel Based on PEG-PCL-PEG Block Copolymers[J]. Journal of biomedical engineering, 2008, 25(5) | |
| Authors: | Gong Changyang Gu Yingchun Xie Zhen Xie Xihui Liu Caibing Kan Bing Tu Mingjing Wei Yuquan Qian Zhiyong |
| Affiliation: | State Key Laboratory of Biotherapy;West China Hospital;Sichuan University;Chengdu 610041;China;Department of Textile and Clothing;Chengdu 610065;China;Jiangyan Hospital of Traditional Chinese Medicine;Jiangyan 225500;China;College of Material Science and Engineering;China |
| Abstract: | In this paper, a series of low-molecular-weight PEG-PCL-PEG triblock copolymers were successfully synthesized by ring-opening polymerization method, and were characterized using 1H-NMR and FTIR. The aqueous solution displayed specific thermosensitive gel-sol transition when the concentration was above corresponding critical gel concentration (CGC). The gel-sol phase diagram was recorded using test tube-inverting method, which was depended on the hydrophilic/hydrophobic balance in macromolecular structure, a... |
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