| 2型糖尿病TNF—α与IR的关系 |
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| 引用本文： | 吴建能,曾顺和,黄幸青,王莉,熊宝莲.2型糖尿病TNF—α与IR的关系[J].中国误诊学杂志,2003,3(10):1469-1470. |
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| 作者姓名： | 吴建能 曾顺和 黄幸青 王莉 熊宝莲 |
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| 作者单位： | 广东省韶关粤北人民医院内分泌科,512026 |
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| 摘 要： | 目的:探讨2型糖尿病血清肿瘤坏死因子与胰岛素抵抗之间的关系。方法:用氧化酶法,放免法和酶联免疫法分别测定正常健康人23例,2型糖尿病28例的空腹血糖、空腹胰岛素(Fins)、血清TNF-α。计算胰岛素敏感指数(ISI)。结果:2型糖尿病TNF-α水平较正常对照组升高(P<0.01),而ISI较正常组降低(P<0.01)。结论:2型糖尿病TNF-α水平增高与胰岛素抵抗有关,可能参与2型糖尿病的发生和发展。
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| 关 键 词： | 糖尿病 非胰岛素依赖型／血液 肿瘤坏死因子／血液 胰岛素抗药性 |
| 文章编号： | 1009-6647(2003)10-1469-02 |
| 修稿时间： | 2003年5月28日 |
Relationship between Sera TNFalevel and Insulin Resistance in Patients with Type 2 Diabetes |
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| WU Jian-neng,ZENG Shun-he,HUANG Xing-qing,et al..Relationship between Sera TNFalevel and Insulin Resistance in Patients with Type 2 Diabetes[J].Chinese Journal of Misdiagnostics,2003,3(10):1469-1470. |
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| Authors: | WU Jian-neng ZENG Shun-he HUANG Xing-qing |
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| Abstract: | Objective:To explore the relationship between sera TNFalevels and insulin resistance in patients with type 2 diabetes. Methods: 23 healthy persons (control group) ,28 cases of type-2 diabetes mellitus were selected to determine fasting blood glucose, fasting blood-insulin and serum TNF-a by oxidase method, RIA and ELISA. Insulin sensitivity index(ISI) was calculated. Results:TNF-a levels were significantly higher while ISI lower in DM group than those in control group(P<0. 01). Conclusions. In type 2 diabetes mellitus the level of TNF-a increased and it was negatively correlated to ISI, which plays an important role in the development of the disease. |
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| Keywords: | Diabetes mellitus non-insulin-dependent/blood Tumor necrosis factor /blood Insulin resistance |
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