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目的探讨川崎病(KD)冠脉瘤远期血管改变及其与冠脉粥样硬化的关系。方法选择首都医科大学附属北京儿童医院2008年6月至2009年6月病程大于1年且合并中型以上冠脉瘤的KD患儿31例为研究对象(KD冠脉瘤组),以CD34/CD133/KDR+为血管内皮祖细胞(EPC)表面分子标记,用流式细胞仪测定血周血EPC数量;采用酶联免疫法测定血清超敏C反应蛋白(hs-CRP);全自动生化分析仪测定血脂及载脂蛋白。选取年龄、性别匹配的21名健康体检儿童作对照(对照组)。结果 KD冠脉瘤组患儿病程1.0～12.5年,中位病程2.5年;中型冠脉瘤9例,巨大瘤22例,12例存在心肌缺血证据。KD冠脉瘤组血清hs-CRP为(2.77±1.06)mg/L,对照组为(1.60±1.53)mg/L,KD冠脉瘤组显著升高(P<0.01)。外周血EPC及血脂两组比较差异无统计学意义(P>0.05)。结论 KD冠脉瘤组恢复期血清hs-CRP显著升高,提示仍有慢性炎症反应,可能与KD成年后早发动脉粥样硬化有关。

The study of circulating endothelial progenitor cells and inflammatory factors in children with coronary aneurysms late after Kawasaki disease

Objectives To evaluate the circulating endothelial progenitor cells(EPC) numbers as well as the serum lipoprotein levels and high sensitivity C-reactive protein(hs-CRP) in children with coronary aneurysms. Methods Thirty-one children with coronary aneurysms due to Kawasaki disease and twenty-one healthy children were enrolled in this study. Circulating EPCs were determined by flow cytometry,defined as CD34,KDR,CD133 possitive cells. Serum lipoprotein levels were measured by using automatic biochemistry anal...