注射用血栓通联合瑞舒伐他汀治疗不稳定型心绞痛的临床研究

目的探讨注射用血栓通联合瑞舒伐他汀钙片治疗不稳定型心绞痛的临床疗效。方法选取2018年1月—2019年5月天津市宁河区医院收治的86例不稳定型心绞痛患者为研究对象,将所有患者按照随机数字表法分为对照组和治疗组,每组各43例。对照组患者口服瑞舒伐他汀钙片,10 mg/次,1次/d。治疗组患者在对照组治疗的基础上静脉滴注注射用血栓通(冻干),250 mg/d,1次/d。两组患者均连续治疗14 d。观察两组患者的心绞痛疗效和心电图疗效,并比较两组的临床症状、内皮功能因子水平和血脂水平。结果治疗组心绞痛的总有效率为95.35%,对照组心绞痛的总有效率为81.40%,两组的心绞痛疗效比较差异有统计学意义(P0.05)。治疗组心电图的总有效率为88.37%,对照组心电图的总有效率为69.77%,两组心电图疗效比较,差异有统计学意义(P0.05)。治疗后,两组发作时间、持续时间、硝酸甘油用量均显著降低(P0.05);治疗后治疗组患者的发作时间、持续时间、硝酸甘油用量比对照组低,差异有统计学意义(P0.05)。治疗后,两组患者一氧化氮(NO)高于治疗前,内皮素1(ET-1)、血管内皮细胞钙黏蛋白(VEC)、血栓素B2(TXB2)低于治疗前(P0.05);治疗后治疗组的NO高于对照组,ET-1、VEC、TXB2低于对照组,差异有统计学意义(P0.05)。两组患者在治疗后的总胆固醇、三酰甘油、低密度脂蛋白胆固醇(LDL-C)水平均明显降低(P0.05),且治疗后治疗组血脂水平比对照组低,差异有统计学意义(P0.05)。结论注射用血栓通联合瑞舒伐他汀钙片治疗不稳定型心绞痛的疗效确切,减轻临床症状,改善血管内皮功能和血脂水平,降低不良反应的发生,具有重要临床研究价值。

Clinical study on Xueshuantong Injection combined with rosuvastatin in treatment of unstable angina pectoris

Objective To investigate the clinical effect of Xueshuantong Injection combined with Rosuvastatin Calcium Tablets in treatment of unstable angina pectoris. Methods Patients (86 cases) with unstable angina pectoris in Tianjin Ninghe Hospital from January 2018 to May 2019 were randomly divided into control and treatment groups, and each group had 43 cases. Patients in the control group were po administered with Rosuvastatin Calcium Tablets, 10 mg/time, once daily. Patients in the treatment group were iv administered with Xueshuantong Injection on the basis of the control group, 250 mg/d, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies of angina pectoris and electrocardiogram efficacies were evaluated, and improvement of angina symptoms, endothelial function factor levels, and blood lipid levels in two groups were compared. Results After treatment, the clinical efficacies of angina pectoris in the control and treatment groups were 81.40% and 95.35%, and the electrocardiogram efficacies in the control and treatment groups were 69.77% and 88.37%, respectively, and there was difference between two groups (P<0.05). After treatment, the attack time, duration and dosage of nitroglycerin in two groups were significantly decreased (P<0.05). And the attack time, duration and dosage of nitroglycerin in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, levels of NO in two groups were significantly increased, but the levels of ET-1, VEC, and TXB2 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the endothelial function factor levels in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the total cholesterol, triglyceride and LDL-C in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the blood lipid levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xueshuantong Injection combined with Rosuvastatin Calcium Tablets has definite curative effect in the treatment of unstable angina pectoris, can relieve the symptoms of angina pectoris, improve the function of vascular endothelium and blood lipid levels, and reduce the occurrence of adverse reactions, which has important clinical research value.