不同大小甲状腺结节的超声造影定量分析

目的：探讨不同大小、不同性质甲状腺结节的超声造影特征.方法：根据甲状腺结节的最长径及手术病理结果将结节分为4组：最长径≥10 mm的恶性结节49个（Ⅰ组）,最长径＜10 mm的恶性结节52个（Ⅱ组）,最长径≥10 mm的良性结节9个（Ⅲ组）,最长径＜10 mm的良性结节8个（Ⅳ组）,应用Qontrast软件对甲状腺结节病灶进行超声造影检查并获得超声造影时间-强度曲线各定量参数,分析不同大小甲状腺结节与周边正常组织间各定量参数的差异性.结果：分析显示Ⅰ组、Ⅱ组与周围正常组织间的峰值强度（PEAK）、达峰时间（TTP）及局部血流量（RBF）差异相互有统计学意义（P＜0.05）;Ⅰ组与Ⅲ组间的PEAK、TTP及RBF差异有统计学意义（P＜0.05）;Ⅱ组、Ⅲ组及Ⅳ组间的PEAK、TTP及RBF差异均无统计学意义（P＞0.05）;各组间局部血容量（RBV）及造影剂平均渡越时间（MTT）差异均无统计学意义（P＞0.05）.结论：超声造影结合时间-强度曲线各参数可能为鉴别甲状腺结节提供参考依据,但各组间造影剂灌注特点仍存有一定的重叠性,无特异性,尚不能作为甲状腺结节定性诊断的方法.

Quantitative analysis of contrast-enhanced ultrasonography in the thyroid nodules of different sizes

Objective：To explore the perfusion and enhancement features of the thyroid nodules in different characteres and different sizes using contrast-enhanced ultrasonography（CEUS）.Methods：According to the length and postoperative pathology of the thyroid nodules,118 thyroid nodules from 99 patients given CEUS were divided into four groups：group Ⅰ：thyroid malignant nodules length of lesion ≥ 10 mm（n=49）,group Ⅱ：thyroid malignant nodules length of lesion ＜10 mm（n=52）,group Ⅲ：thyroid benign nodules length of lesion ≥10 mm （n=9）,group Ⅳ：thyroid benign nodules length of lesion ＜10mm （n=8）.The parameters from time-intensity curve of thyroid nodules and the adjacent thyroid parenchyma were acquired through Qontrast software,including peak intensity（PEAK）,Time-To-Peak（TTP）,regional blood volume（RBV）,regional blood flow（RBF） and mean transit time（MTT）.The quantitative analysis findings of CEUS of each group and their adjacent thyroid parenchyma were compared adopting analysis of variance.Results：There were significant difference in PEAK,TTP and RBF among group Ⅰ,group Ⅱ and their adjacent thyroid parenchyma.There were significant difference in PEAK,TTP and RBF between group Ⅰ and group Ⅲ.While there were no significant difference in PEAK,TTP and RBF among group Ⅱ,group Ⅲ and group Ⅳ.And there were no significant difference in RBV and MTT among each groups.Conclusions：The data of this study suggested that up to now overlapping and lacking specificity findings had seen in the characteristics of each group of thyroid nodules.CEUS combined time-intensity curve can provide efficient and supplementary information but can not differentiate the specific type of thyroid nodules.