| 化疗联合CIK细胞治疗转移性胰腺癌的临床观察 |
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| 引用本文： | 王子兵,尚艺曼,张勇,高全立.化疗联合CIK细胞治疗转移性胰腺癌的临床观察[J].实用医药杂志(山东),2013(11):967-968. |
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| 作者姓名： | 王子兵 尚艺曼 张勇 高全立 |
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| 作者单位： | 郑州大学附属肿瘤医院/河南省肿瘤研究院,河南郑州450008 |
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| 基金项目： | 国家自然科学基金青年科学基金项目（81000914）;河南省科技攻关计划重大项目（2011010011） |
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| 摘 要： | 目的观察化疗联合CIK细胞治疗转移性胰腺癌的疗效及安全性。方法回顾性分析入住笔者所在科行化疗联合CIK细胞治疗的11例转移性胰腺癌患者的临床资料。这些患者均接受按体表面积计量的吉西他滨和/或替吉奥化疗药物,然后在化疗用药结束后的第25 d回输CIK细胞。观察指标包括疾病控制率、中位生存时间、1年生存率和不良反应。结果 11例中无完全缓解者,3例部分缓解,6例病情稳定,2例病情进展,疾病控制率为81.82%。中位生存时间为14.87个月,1年生存率为72.73%。不良反应如下:骨髓抑制4例,腹泻2例,乏力、纳差1例。结论化疗联合CIK细胞治疗转移性胰腺癌,疗效和耐受性较好,可明显提高患者生存时间。
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| 关 键 词： | 胰腺癌 化疗 CIK细胞治疗 |
Efficacy and safety of CIK cell therapy combined with chemotherapy in patients with pancreatic cancer |
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| Institution: | WANG Zi - bing, SHANG Yi - man, ZHANG Yong, et all The Oncology Hospital Affiliated to Zhengzhou University/ Henan Provincial Oncology Hospital, Zhengzhou, 450008, Henan, China |
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| Abstract: | Objective To observe the efficacy and safety of chemotherapy and CIK cell therapy for advanced pan- creatic cancer. Methods A retrospective analysis of 11 advanced pancreatic cancer cases receiving chemotherapy com- bined with CIK cell therapy was made by authors. All these patients received gemcitabine and/or S - 1 combined with CIK cell therapy. Disease control rate, median survival time, 1 -year survival rate and adverse reaction were observed. Results Disease control rate was 81.82%, i e,no cases of CR, 3 cases of PR, 6 cases of SD, and 2 cases of PD. The median survival time was 14. 87 months and 1 - year survival rate was 72. 73%. The adverse reaction included 4 cases of hemato- logical toxicity, 2 cases of diarrhea, and 1 case of fatigue weakness. Conclusion Chemotherapy combinde with CIK cell therapy can significantly prolong survival of advancde pancreatic cancer patients. |
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| Keywords: | Pancreatic cancer Chemotherapy CIK cell therapy |
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