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| 不同剂量竹叶对关木通中马兜铃酸A溶出量的影响实验研究 | |
| 引用本文： | 王亮,丁里玉,丁芳,李春香,朱晓卉,郝蕾.不同剂量竹叶对关木通中马兜铃酸A溶出量的影响实验研究[J].时珍国医国药,2009,20(11). |
| 作者姓名： | 王亮 丁里玉 丁芳 李春香 朱晓卉 郝蕾 |
| 作者单位： | 1. 河北医科大学第三医院,河北,石家庄,050017 2. 河北医科大学药学院,河北,石家庄,050091 3. 河北医科大学中医学院,河北,石家庄,050091 4. 河北省石家庄市长安区医院,050017 |
| 基金项目： | 河北省中医管理局资助课题 |
| 摘 要： | 目的 观察不同剂量竹叶对关木通中马兜铃酸A溶出量的影响.方法 采用反相高效液相色谱法测定不同剂量竹叶配伍关木通中马兜铃酸A的溶出量.结果 关木通马兜铃酸A溶出量为0.106 mg/ml;竹叶与关木通1∶4配伍其溶出量为0.041 mg/ml.结论 中药竹叶可明显降低关木通马兜铃酸A溶出量61%;竹叶与关木通以1∶4配比对其马兜铃酸A的溶出量降低最明显. |
| 关 键 词： | 竹叶 关木通 配伍 马兜铃酸A 肾毒性 |
Experimental Study on Reducing the Dissolution of Aristolochic Acid A in Aristolochiae manshuriensis by Different Doses of Bamboo Leaf |
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| WANG Liang,DING Li-yu,DING Fang,LI Chun-xiang,ZHU Xiao-hui,HAO Lei.Experimental Study on Reducing the Dissolution of Aristolochic Acid A in Aristolochiae manshuriensis by Different Doses of Bamboo Leaf[J].Lishizhen Medicine and Materia Medica Research,2009,20(11). | |
| Authors: | WANG Liang DING Li-yu DING Fang LI Chun-xiang ZHU Xiao-hui HAO Lei |
| Abstract: | Objective To observe the effects of the dissolution of aristolochic acid A in Aristolochiae manshuriensis by different doses of bamboo leaf. Methods The dissolution of aristolochic acid A in different dose bamboo leaf mixed with Aristolochiae manshuriensis was determined by RP - HPLC. Results ①The dissolution of aristolochic acid A was 0.106 mg/ml in aristolochiae manshuriensis.②The dissolution of aristolochic acid A was 0.041 mg/ml in bamboo leaf mixed with Aristolochiae manshuriensis (the ratio of bamboo leaf and Aristolochiae manshuriensis was 1:4 ). Conclusion ①Bamboo leaf can obviously reduce the dissolution of aristolochic acid A to 61 %.②When the ratio of bamboo leaf and Aristolochiae manshuriensis is 1:4, the reduction of dissolution of aristolochic acid A is the most significant. |
| Keywords: | Bamboo leaf Aristolochiae manshuriensis Compatibility Aristolochic Acid A Nephrotoxicity |
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