彩色多普勒超声评价肝硬化患者眼动脉、视网膜中央动脉血流动力学变化

目的:应用彩色多普勒超声技术(CDFI)检测肝硬化患者眼动脉(OA)、视网膜中央动脉(CRA)血流参数,旨在探讨肝硬化不同程度肝功能与外周末梢血管血流动力学改变的关系及其临床意义。方法:56例乙肝后肝硬化患者按child-pugh分为A级,B级,C级三个组,50例健康成人为对照组,应用CDFI探查眼动脉、视网膜中央动脉,记录收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV)和阻力指数(RI)。结果:肝硬化组B、C组眼动脉、视网膜中央动脉的PSV、EDV均明显高于对照组及A组,EDV增加的幅度高于PSV增幅,RI显著减低。结论:彩色多普勒超声检测眼动脉、视网膜中央动脉血流动力学变化,表明肝硬化患者外周末梢动脉处于高动力循环状态,其对肝硬化的诊断及预后评价有重要的临床意义。

Changes of the hemodynamics of ophthalmic artery and central retinal artery revealed by color Doppler ultrasound in patients with liver cirrhosis

Objective:To observe the changes of the hemodynamics the ophthalmic artery(OA)and central retinal artery(CRA)' and discuss the relationship between the degree of liver function and the alterations of peripheral arterial parameters and clinical significance.Methods:56 patients with cirrhosis were divided into 3 groups(grades A,B,C)by child-pugh scores.The peak systolic velocity(PSV),end-diastolic velocity(EDV)and resistance index(RI)of ophthalmic artery and central retinal artery in patients with cirrhosis and 50 healthy subjects were examined by color Doppler ultrasonography.Results:Compared with the patients of grade A and contrast group,the PSV and EDV in patients of grade B and C were markedly increased,the amplitude of EDV was slightly higher than that of PSV,In child-pugh grade A,B and C group patients,the RI was significantly decreased.Conclusions:The changes of the blood flow of ocular vascular detected by Color Doppler ultrasound showed that the hyperdynamics existed in end-brush perivascular,and it played an important role in the diagnosis and the evaluation of therapeutic effect in patients with liver cirrhosis.