人乳头瘤病毒和单纯疱疹病毒与宫颈癌的关系

目的探讨人乳头瘤病毒（HPv）和单纯疱疹病毒（HSV）等对宫颈癌的病因学作用。方法应用聚合酶链反应（PCR）-核酸内切酶分型检测宫颈癌活检组织中HPV—DNA和HSV—DNA基因，以正常宫颈组织作对照。结果在宫颈癌活检组织中HPV-16，18，35型和HSV—Ⅱ型阳性率分别为38．9％争36．2％，与正常妇女宫颈组织阳性率均为3．2％比较，差异均有非常显著意义（P〈0．001）。结论HPV-16，18型和HSV-Ⅱ型是诱发宫颈癌的重要病原因子。

The relationship between human papillomavirus and herpes simplex virus and cervical carcinoma

Objective This study was to detect the human papillomavirus （HPV） and herpes simplex virus （HSV） genotypes in biopsy specimens of cervical Carcinoma and genital verruca by PCR - endonuclease cleavage. Methods Biopsy samples of were obtained from 240 pa- tients with cervical carcinoma, HPV and HSV genotypes were detected by PCR and endonuclease cleavage. Results The results indicated that HPV types 16, 18, 35 were found in 93 （38.9%） of 240 cervical carcinoma, in 85（31.7% ） of 268 cervical erosion, while HPV types 6, 11 were found in 51 （59.3 % ） of 86 acuminate erruca. The HPV 16, 18 types and HSV - Ⅱ type found in normal cervical secretions of the con- trul group all were 3.2%, There was significant difference between the test group of cervical carcinoma and the control group of normal cervical secretion （P〈 0.001）. Conclusion The results-suggest that HPV 16, 18 ,35types and HSV -Ⅱ type are associated with majority of the cer- vical carcinoma.