铜绿假单胞菌和鲍曼不动杆菌临床感染和耐药性分析

目的探讨铜绿假单胞菌和鲍曼不动杆菌的筘床感染分布及其药敏情况，为临床合理使用抗菌药物和预防多重耐药菌株的产生提供依据。方法回顾性分析了642株铜绿假单胞茼和570株鲍曼不动杆菌感染科室分布及耐药情况。结果铜绿假单胞菌和鲍曼不动杆菌感染的科室主要集中在重症监护病房（ICU）、呼吸科、神经外科、神经内科；氨苄西林和头孢唑啉对铜绿假单胞菌和鲍曼不动杆茸的抗菌作用最差，耐药率大于95％；铜绿假单胞茴对亚胺培南、美洛培南、头孢哌酮／舒巴坦、多粘菌素敏感性最高；鲍曼不动杆菌对亚胺培南和美罗培南的敏感性有所降低，其耐药率在15％左右，对多粘菌素的敏感性最高。结论铜绿假单胞菌争鲍曼不动杆茼临床分离株多来自ICU病房；氨苄西林和头孢唑啉已经不适于铜绿假单胞菌和鲍曼不动杆菌感染的治疗，亚胺培南、芙洛培南、多粘茼素可作为临床经验性用药；临床应重视合理使用抗生素，加强对铜绿假单胞菌和鲍曼不动杆菌的耐药性监蒯，减少多重耐药菌的产生。

Clinical infection and drug resistance analysis of Pseudomonas aeruginosa and Acinetobacter baumannii

Objective To investigate the distribution and drug resistance state Of Pseudomonas aeruginosa and Acinetobaeter baumannii, so as to offer reasonable experimental data for the rational use of antibiotics and preventing the development of multi - drug bacteria. Methods A retrospective method was employed to analyze the distribution of departments and drug resistance from 642 strains Pseudomonas aeroglnosa and 570 strains Acinetobacter baumannii. Results Among Pseudomonas aeruginesa and Acinetobacter baumannii, the most came from ICU, depart- ment of respiratory disease, department of neurosurgery and department of neurology. The most insensitive antibiotic were AmpieiUin and Cefa- zolin, drug resistance rate was more than 95%, The most sensitive antibiotic were Imiponem, Meropenem, Cefoporuzone/sulbactam and Polymyxin for P. aeruginesa, Acinetobacter banmarmii to Imipenem and Meropenem sensitivity decreased, the resistant rate was about 15%, The most sensitive antibiotic was Polymyxin. Conclusion Clinical isolates of P. aeruginosa and A. baumannii mostly came from ICU, Ampi- cillin and Cdazolin were not fit for P. aeruginesa and A . batmmnnii the treatment of infection, Imipenem , Meropenem and Polymyxin may be considered the drug of choice in the treatment of the infections caused by the two bacteris, Clinical should attach importance to the use of an- tibiotics reasonable, strengthen drug resistance monitoring and reduce the muff- drug resistance bacteria.