| 中国肺结核治疗失败影响因素的Meta分析 |
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| 引用本文： | 黄建英,钟球,周琳,陈亮,陈维清.中国肺结核治疗失败影响因素的Meta分析[J].疾病控制杂志,2014(2):102-107. |
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| 作者姓名： | 黄建英 钟球 周琳 陈亮 陈维清 |
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| 作者单位： | [1]中山大学公共卫生学院医学统计学与流行病学系,广东广州510080 [2]广东省结核病控制中心主任办,广东广州510630 [3]广东省结核病控制中心门诊部,广东广州510630 |
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| 基金项目： | 十二五“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项（2012ZX10004903） |
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| 摘 要： | 目的探讨肺结核治疗失败的影响因素，为今后防治工作提供依据。方法对PubMed、CNKI、VIP、CBM及万方数据库进行检索关于肺结核治疗失败影响因素的研究（2002—2012年），通过Meta分析，报告危险因素的合并OR（95％CI）值。结果共纳入符合标准的文献15篇，单因素分析，合并OR（95％CI）值分别为：合并症2．71（1．99～3．70）、肺病空洞2．16（1．75～2．66）、病变肺野数4．88（2．76～8．62）、低蛋白血症3．57（2．61～4．90）、不规律治疗28．09（4．90—161．06）、治疗延误〉3个月5．42（1．53—19．15）、吸烟3．47（2．20～5．46）、不良反应2．08（1．46～2．98）、耐药3．30（1．24—8．76）；多因素分析，OR（95％CI）值分别为：合并症2．51（1．85～3．41）、肺部空洞1．77（1．39—2．26）、病变肺野数1．38（1．26～1．51）、不规律治疗19．83（2．83—138．76）、治疗延误〉3个月2．35（1．42～3．91）、不良反应2．14（1．49—3．06）、耐药2．45（1．37—4．38），指标差异均有统计学意义。结论合并症、肺部空洞、病变肺野数、低蛋白血症、不规律治疗、治疗延误、吸烟、不良反应、耐药均是肺结核治疗失败的影响因素。
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| 关 键 词： | 结核 肺 治疗失败 Meta分析 |
Meta-analysis of risk factors on pulmonary tuberculosis treatment failure in China |
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| HUANG Jian-ying,ZHONG Qiu,ZHOU LinE,CHEN Liang,CHEN Wei-qing.Meta-analysis of risk factors on pulmonary tuberculosis treatment failure in China[J].Chinese Journal of Disease Control and Prevention,2014(2):102-107. |
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| Authors: | HUANG Jian-ying ZHONG Qiu ZHOU LinE CHEN Liang CHEN Wei-qing |
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| Institution: | 1. Department of Medical Statistics and Epidemiology, School of Public Health,SunYat-Sen University, Guangzhou 510080, China; 2. Director of the Center for Anti-tuberculosis Research Institute of Guangdong Province, Guangzhou 510630, China; 3. Department of Outpatient, Anti-tuberculosis Research In- stitute of Guangdong Province, Guangzhou 510630, China |
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| Abstract: | Objective To synthetically evaluate the risk factors of pulmonary tuberculosis treatment failure in Chi- na and provide evidence for further study and intervention. Methods PubMed, CNKI,VIP,CBM and Wan Fang database were searched for the studies on the risk factors of tuberculosis treatment failure（2002 -2012）. Pooled OR and their 95 % CI were estimated using data extracted from those papers. Results A total of 15 studies were included~ The merged OR values and their 95% C1 of single-factor-analysis for complications, status of cavitas, numbers of lung lobes lesion, hy- poalbuminemia, irregular therapy, time of delayed treatment （ more than three month）, smoking, adverse reaction, drug re- sistance were as follows ： 2. 71 （ 1.99-3.70 ）, 2. 16 （ 1.75-2. 66 ）, 4. 88 （ 2. 76-8.62 ）, 3.57 （ 2. 61-4. 90 ）, 28.09 （ 4. 90- 161.06） ,5.42（ 1.53-19. 15） ,3.47（2. 20-5.46）, 2.08（ 1.46-2. 98）, 3.30（1.24-8.76）. And the merged OR values and their 95% CI of multiple-factor-analysis for complications, status of cavitas,numbers of lung lobes lesion, irregular thera- py, time of delayed treatment （ more than three month ） , adverse reaction, drug resistance were as follows ： 2. 51 （ 1.85- 3.41）,1.77（1.39-2.26）,1.38（1.26-1.51）, 19.83（2.83-138.76）, 2.35 （1.42-3.91）,2.14（1.49-3.06）,2.45 （ 1.37-4. 38）. All of those factors were statistically significant. Conclusions Complications, status of cavitas, numbers of lung lobes lesion, hypoalbuminemia, irregular therapy, time of delayed treatment （more than three month）, smoking, ad- verse reaction, drug resistance were considered to be the risk factors of pulmonary treatment failure. |
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| Keywords: | Tuberculosis pulmonary Treatment failure Meta-analysis |
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