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清开灵注射液致170例不良反应文献分析
引用本文:刘小丰,宋沧桑,张小青. 清开灵注射液致170例不良反应文献分析[J]. 中国医院用药评价与分析, 2006, 6(4): 243-245
作者姓名:刘小丰  宋沧桑  张小青
作者单位:昆明延安医院药剂科,昆明市,650051
摘    要:
目的:探讨清开灵注射液不良反应发生的特点。方法:检索1994年~2005年国内医学期刊报道应用清开灵注射液所致不良反应案例,并进行统计分析。结果:清开灵注射液不良反应的发生与性别年龄无关,临床表现主要为过敏反应,严重者出现过敏性休克;不良反应在30min内发生者有110例,占64.71%;首次用药发生者有151例,占88.82%,提示不良反应以首用即发型和速发型为主。结论:临床医师、药师应重视清开灵注射液的不良反应,坚持合理用药。

关 键 词:清开灵注射液  药物不良反应  分析
文章编号:1672-2124(2006)04-0243-03
修稿时间:2006-04-11

Adverse Drug Reactions Induced by Qingkailing Injection: Literature Review on 170 Cases
LIU Xiaofeng,SONG Cangsang,ZHANG Xiaoqing. Adverse Drug Reactions Induced by Qingkailing Injection: Literature Review on 170 Cases[J]. Evaluation and Analysis of Drug-Use in Hospital of China, 2006, 6(4): 243-245
Authors:LIU Xiaofeng  SONG Cangsang  ZHANG Xiaoqing
Abstract:
OBJECTIVE: To discuss the features of qingkailing injection-induced ADRs.METHODS: Qingkailing injection-induced ADR cases reported in domestic pharmaceutical journals from 1994 to 2005 were retrieved and analyzed statistically.RESULTS: The ADRs induced by qingkailing injection were independent of patient's sex and age.Its chief clinical manifestations were allergic reactions or anaphylactic shock in serious cases.Of the total ADR cases induced by qingkailing injection,110(64.71%) occurred within 30 min after injection,151(88.82%) occurred in the initial user,which showed that the ADRs characterized by immediate type on initial use and tachy type.CONCLUSION: Clinical physicians and pharmacists should be alert to the ADRs induced by qingkailing injection;meanwhile they should follow rational use of drugs.
Keywords:qingkailing injection  adverse drug reaction(ADR)  analysis
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