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Regulatory interactions between members of the immunoglobulin superfamily
Authors:P Anderson  C Morimoto  J B Breitmeyer  S F Schlossman
Affiliation:1. Galapagos NV, Mechelen, Belgium;2. Deparment of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA, USA;3. Oncology Biomarker Development, Genentech, South San Francisco, CA, USA;4. University of Birmingham, Department Biochemistry, Birmingham, UK;5. Protein Chemistry, Genentech, South San Francisco, CA, USA;6. Bioinformatics, Genentech, South San Francisco, CA, USA;7. BioMolecular Resources Department, Genentech, South San Francisco, CA, USA;8. Research Materials group, Genentech, South San Francisco, CA, USA;9. Biochemistry and Molecular Pharmacology, Genentech, South San Francisco, CA, USA;10. Denali Therapeutics, South San Francisco, CA, USA;11. 23 and me, South San Francisco, CA, USA;12. Cancer Immunology Department, Genentech, South San Francisco, CA, USA
Abstract:
The superfamily of molecules with immunoglobulin-like domains now contains numerous molecules of increasingly diverse structure and function. In this article, Paul Anderson and colleagues discuss how weak interactions between those members present on a given T cell may modulate its activation, by altering the molecular environment around the T-cell receptor. They also suggest that the surface molecules 2H4/4B4 may further influence this modulation through their interaction with members of the superfamily.
Keywords:
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