阿尔茨海默病海马磁共振波谱研究

目的：探讨阿尔茨海默病（AD）海马代谢物的变化及^1H—MRS对早期AD的诊断价值。方法：20例AD患者和20例健康志愿者（对照组）行双侧海马磁共振^1H—MRS扫描，测量双侧海马N-乙酰天门冬氨酸（NAA）、胆碱复合物（Cho）、肌酸和磷酸肌酸（Cr）和肌醇（MI）的峰下面积，计算NAA／Cr、MI／Cr、MI／NAA和Cho／Cr，比较2组间的差异；20例AD患者按照MMSE评分分为轻度组和重度组各10例，进行组间对照研究。结果：AD组与对照组比较，双侧海马NAA／Cr降低，MI／Cr升高，MI／NAA明显升高，两组间NAA／Cr、MI／Cr和MI／NAA的差异有显著性意义（P〈0．05）；重度AD组的MI／NAA较轻度AD组升高，两组间差异有显著性意义（P〈0．05）。结论：^1H—MRS能有效检测AD患者脑组织物质代谢变化，对早期AD的诊断提供重要依据，并揭示脑神经元活性降低、丢失和神经胶质细胞的增生与痴呆程度呈正相关。

Study of ~1H MR Spectroscopy in Hippocampus Metabolites of Alzheimer Disease

Objective:Using 1H-MR spectroscopy(1H-MRS) to investigate the changes of hippocampus metabolites in Alzheimer disease(AD),in order to understand the value of 1H-MRS in the early diagnosis of AD.Methods:20 patients with AD and 20 healthy adults were chosen and their bilateral hippocampus were studied with 1H-MRS.The values of N-acetylaspartate(NAA),creatine and phosphocreatine(Cr),myo-inositol(MI) and choline-containing phosphocholine and glycerol-phosphocholine(Cho) of bilateral hippocampus were measured,th...