Differential mood changes following basal ganglia vs thalamic lesions |
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| Authors: | S E Starkstein R G Robinson M L Berthier R M Parikh T R Price |
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| Affiliation: | Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD. |
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| Abstract: | Patients with computed tomographic scan-verified unilateral lesions in the basal ganglia or thalamus were examined for the presence of poststroke mood disorders. Patients with left-sided basal ganglia lesions (mainly in the head of the caudate nucleus) showed a significantly higher frequency and severity of depression, as compared with patients with right-sided basal ganglia or thalamic (left- or right-sided) lesions. Results suggest that damage to biogenic amine pathways and/or frontocaudate projections may play an important role in the modulation of mood. |
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