半枝莲黄酮类化合物体外抗肿瘤活性的研究

目的 研究半枝莲中黄酮类化合物的体片抗肿瘤活性.方法 采用MTT法,测定半枝莲药材中的5个黄酮类化合物(木犀草素、野黄苓苷、黄苓素、芹莱素,4'-羟基汉黄苓素)休外分别对人肝癌细胞株HepG-2、人结肠癌细胞株SW480、人胃癌细胞株MGC-803、急性早幼拉细胞白血病细胞株HL-60、人红白血病细胞株K562的增殖抑...

Anti-tumor Active of Flavonoids in Scutellaria Barbata D.Don in vitro

OBJECTIVE To study the anti-tumor active of flavonoids extracted from Scutellaria Barbata D. Don in vitro. METHOD MTT method was used to test inhabitation of five flavonoids（luteolin, scutellarin, apigenin, baicalein, 4＇-hydroxywogonin）from Scutellaria Barbata D. Don with five kinds of human tumor cells in vitro and IC50 values were calculated, respectively. RESULT ICs0 values of these flavonoids （luteolin, seutellarin, apigenin, baicalein, 4＇-hydroxywogonin）tested with five cancer cell lines were 10.3- 30.8μg·mL^-1, 15.2 35.1μg·mL^-1,5.9-- 40.0μg·mL^-1, 6.3 -- 40.3μg·mL^-1 and 8.3 -- 38.4μg·mL^-1, respectively. Conclusion To some extent, these five flavonoids from Scutellaria Barbara D.Don have positive effect on inhabiting those human tumor lines in vitro.