235例宫颈细胞学ASCUS诊断的临床意义

目的探讨性质未定的不典型鳞状细胞(ASCUS)的临床意义。方法对3856例患者行宫颈液基细胞学检查(LCT),其中235例被诊断为ASCUS。采用杂交捕获法(HC2)检测13种高危型HPV—DNA,通过阴道镜,对可疑病灶行多点活检。结果HPV-DNA阳性患者108例(46．0％),其中CIN阳性66例(61．0％);HPV-DNA阴性患者127例(54．0％),其中CIN阳性15例(12．0％)。HPV-DNA阴性对高度鳞状上皮内病变(HSIL)阴性预测值98．0％。结论对ASCUS患者应行HPV检测和阴道镜下活检,进一步明确诊断。HPV—DNA高危型检查更具预测价值。

The Significance of Cervico-cytologically Diagnosed ASCUS(An Analysis of 235 Cases)

Objective To explore the clinical meaning of "atypical squamous cell of undetermined significance" (ASCUS) diagnosed by liquid-based cytology test (LCT).Methods LCT was applied to 3856 cases of patient from 2003.11~ 2004.12 in which 235 cases were diagnosed as ASCUS. In these 235 patients 13 types of HPV-DNA with highrisk were detected by hibridization-catch method(HC2),and cervical biopsies at suspicious foci were carried out for pathological observation.Results 127 patients(54.0%) were determined as HPV-DNA-negative,among them,only 15 cases(11.8%) were observed suffering from CIN(cervical intraepithelial neoplasia),while in HPV-DNA-positive patients(108 cases,46.0%),the CIN-incidance was 61.1% (P<0.01) .The negative forecast rate of HPV(-) to HSIL(-) was 98%.Conclusion The patients with ASCUS should receive HPV-DNA detection and pathological examination. HPV-DNA highrisk examination should have more forecast value.